Although opioids may cause temporary mood improvement, long-term use can lead to onset of depression, a recent study warns.
The study investigated various opioids including pentazocine, levorphanol, hydromorphone, meperidine, oxymorphone, fentanyl, codeine and morphine.
Prolonged opioids use including morphine use can control pain symptoms; however cause newer onset of depression, said Dr. Jeffrey Scherrer, associate professor at the St. Louis University, USA.
Clinicians and patients should be aware that opioids use over 30 days poses significant risk of new onset of depression. Prescription of long-term opioids use should be reconsidered in individuals with depression and mood problems, the researcher noted.
The study was published in the Annals of Family Medicine.