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Febuxostat information from DrugsUpdate  

See Available Brands of Febuxostat in India

Febuxostat, a xanthine-oxidase inhibitor, is indicated for the treatment of gout. Febuxostat lowers the plasma uric acid levels and prevents acute gout attacks. However, the drug is not useful once the symptoms occur.

Pharmacodynamics

Febuxostat selectively inhibits the xanthine oxidase and lowers circulating levels of uric acid. However, the drug does not interfere with other enzymatic pathways of purine and pyrimidine biosynthesis.

Pharmacokinetics

After oral administration, Febuxostat is moderately absorbed. The absorption, Cmax and AUC of Febuxostat are influenced by high fat meals and antacids with aluminium and/or magnesium. The steady-state Vss of Febuxostat is about 50 L. The plasma albumin binding capacity of Febuxostat is 99.2%. The drug is extensively metabolized via hepatic cytochrome P450 enzymes, hepatic oxidation and by conjugation via uridine diphosphate glucuronosyltransferase (UGT). The drug is mostly excreted in urine and feces as glucuronide and oxidative metabolites.

Febuxostat Indications / Febuxostat Uses

No information available

Febuxostat Adverse Reactions / Febuxostat Side Effects

Some of the commonly reported adverse events of Febuxostat are angina pectoris, ECG anomalies, blood cell count anomalies, splenomegaly, changes in vision, vertigo, tinnitus, hepatitis, hypersensitivity, fatigue, pancreatitis, GI ulcer, vomiting, gingivitis, dyspepsia, gastritis, flu-like symptoms, cholelithiasis, hepatitis, contusion, salt imbalance, myalgia, metabolic syndrome, musculoskeletal disorders, behavioural changes, tremors, hematuria, incontinence, impotence, alopecia and hot flush.

Precautions

Febuxostat is contraindicated in patients with renal disorders, cancer, stroke, liver failure, organ transplanted patients and chest pain. Adjusted dosage is needed if symptoms of gout flare, CVD events and hepatic effects are observed.

Special Precautions

Information not available

Other Drug Interactions

Febuxostat should not be used concomitantly with xanthine oxidase substrate drugs, theophylline, azathioprine, mercaptopurine and other cytotoxic chemotherapeutic drugs.

Other Interactions

Information not available

Dosage

For treatment of Hyperuricemia and Gout (Adults):
The recommended dose of Febuxostat is 40-80 mg, once daily. The dosage should be titrated based on the clinical response and serum uric acid levels (less than 6 mg/dL).

Food(before/after)

Febuxostat can be taken before or after meals

List of Contraindications

Febuxostat and Pregnancy

USFDA pregnancy category C. Febuxostat may or may not cause harm to an unborn foetus. Before Febuxostat treatment, the patient should discuss with the physician, if they are planning for a pregnancy.

Febuxostat and Lactation

It is not known whether Febuxostat can pass through the breast milk or not. Breastfeeding mothers should avoid nursing while taking Febuxostat.

Febuxostat and Children

Information not available

Febuxostat and Geriatic

Information not available

Febuxostat and Other Contraindications

Information not available

Storage

Store below 25°C. Protect from light.

Lab interference

Store below 25°C. Protect from light.

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