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Bimatoprost information from DrugsUpdate  

See Available Brands of Bimatoprost in India

Bimatoprost ophthalmic solution, a prostaglandin analogue, is indicated for the reduction of intraocular pressure (IOP) by increasing the outflow of aqueous humor from the eye chamber. Bimatoprost ophthalmic solution is effective against glaucoma and other eye disorder that cause IOP. Bimatoprost ophthalmic solution improves length, density and colour of eyelashes in hypotrichosis patients.

Pharmacodynamics

Mechanism of Action

The drug mimics the pharmacological action of prostamides. Bimatoprost increase draining of aqueous humor via trabecular mesh and uveoscleral routes and thereby reduce intraocular pressure.

Pharmacokinetics

Absorption: The peak blood concentration of 0.03% Bimatoprost ophthalmic solution (one drop) was observed within ten minutes after administration. The mean Cmax and AUC 0-24 hours values are same on days 7 and 14, after administration of 0.08 ng/mL and 0.09 ng/mL. The drug reaches the steady state within the first week of treatment. No incidences of drug accumulation were reported in clinical trials.


Distribution: The steady state volume of Bimatoprost ophthalmic solution is 0.67 L/kg, indicative of moderate tissue distribution of the drug. About 12% of administered Bimatoprost remains unbound to plasma proteins.


Metabolism: Bimatoprost ophthalmic solution is metabolized by oxidation, glucuronidation and N-deethylation processes that result in formation of several drug metabolites.


Elimination: The maximum plasma concentration of unchanged Bimatoprost ophthalmic solution is 12.2 ng/mL with plasma half-life of about 45 minutes. The plasma clearance of the drug is 1.5 L/hr/kg. Up to 67% of the administered drug is eliminated via urine and the remaining by stools.

Bimatoprost Indications / Bimatoprost Uses

No information available

Bimatoprost Adverse Reactions / Bimatoprost Side Effects

Bimatoprost ophthalmic solution may cause vision changes, photophobia, itching/pain with redness of eyes, watery eyes, eye discomfort and dizziness, burning or stinging of eyes.

Precautions

Bimatoprost ophthalmic solution may cause gradual brown discoloration of eyes or eyelids colour with increased growth of eyelashes. Colour change could be irreversible even after years of treatment discontinuation. Avoid overdose of Bimatoprost. It may result in drug tolerance.

Special Precautions

No information available

Other Drug Interactions

No information available

Other Interactions

No information available

Dosage

Bimatoprost ophthalmic solution is available in two dosage forms including Bimatoprost 0.1 mg/mL or Bimatoprost 0.3 mg/mL.

Food(before/after)

No information available

List of Contraindications

Bimatoprost and Pregnancy

USFDA pregnancy category C. May be or may not be harmful to an unborn baby. Consult your doctor if you are in gestation or planning to have a baby during Bimatoprost treatment.

Bimatoprost and Lactation

Nursing mothers should consult the healthcare provider before Bimatoprost treatment.

Bimatoprost and Children

Bimatoprost is generally not prescribed in individuals less than 21 years old.

Bimatoprost and Geriatic

No information available

Bimatoprost and Other Contraindications

No information available

Storage

Store at 20-25°C.

Lab interference

Store at 20-25°C.

Bimatoprost brands in India:

Bitoma Careprost Careprost Plus Ganfort Lumigan

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