L-Arginine information from DrugsUpdate
L-Arginine is a non-essential amino acid that is biosynthesized by protein metabolism. In certain cases, such as chronic infections and trauma, biosynthesis of L-Arginine is impaired in humans that result in biochemical abnormalities. Individuals without endogenous L-Arginine need external supplementation, and in such cases L-Arginine is considered as a semi-essential amino acid. Foods such as peanuts, milk, eggs and soy proteins are the richest sources of L-Arginine.
Pharmacodynamics
No information available
Pharmacokinetics
No information available
L-Arginine Indications / L-Arginine Uses
No specific information
L-Arginine Adverse Reactions / L-Arginine Side Effects
Hypotension, nausea and diarrhoea are some of the reported adverse events of L-Arginine. IV administration of L-Arginine may increase the risk of metabolic acidosis in patients with electrolytic imbalance. In hepatic and renal disorder patients, L-Arginine can cause hypokalemia and azotemia due to impaired serum clearance.
Precautions
Do not use L-Arginine in case of recent clinical history of acute heart attack.
Special Precautions
No specific information
Other Drug Interactions
Some drugs such as statins and insulin may interact with L-Arginine. The plasma levels of isosorbide mononitrate, sodium nitroprusside and glyceryl trinitrate may be increased following L-Arginine administration.
Other Interactions
No specific information
Dosage
Oral dose of 6 – 30 g/day is being formulated in various brands for treatment of different ailments.
Food(before/after)
No specific information
List of Contraindications
L-Arginine and Pregnancy
Clinical trial data supporting safety and efficacy of L-Arginine in pregnancy and lactation is lacking. However, no significant adverse events are reported in gestational women.
L-Arginine and Lactation
No specific information
L-Arginine and Children
No specific information
L-Arginine and Geriatic
No specific information
L-Arginine and Other Contraindications
No specific information
Storage
Store at room temperature
Lab interference
Store at room temperature
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