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Buclizine information from DrugsUpdate  

See Available Brands of Buclizine in India

P - Caution when used during Pregnancy.

Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclozine.

Pharmacodynamics

Buclizine is a piperazine antihistamine with antimuscarinic and moderate sedative properties. It is used mainly for its antiemetic action and in the treatment of migraine in combination with analgesics.

Buclizine Indications / Buclizine Uses

It is used as prophylaxis of motion sickness; in the treatment of migraine, nausea, vomiting and pruritic skin disorders.

Buclizine Adverse Reactions / Buclizine Side Effects

Drowsiness, dizziness, incoordination; blurred vision; urinary retention; vomiting; rash; dry mouth; headache, nausea, epigastric pain, wt gain and diarrhoea.

Special Precautions

Driving or operating machinery; open-angle glaucoma; urinary retention; prostatic hyperplasia, pyloroduodenal obstruction, epilepsy; renal and hepatic impairment; pregnancy.

Other Drug Interactions

Potentially Fatal: Effect of alcohol, sedatives and other CNS depressants potentiated.

Dosage

Oral

Prophylaxis of motion sickness

Adult: As hydrochloride: 25 or 50 mg given 30 min before travelling, repeated after 4-6 hr, if necessary.

Oral

Migraine

Adult: As hydrochloride: 12.5 mg taken as soon as symptoms arise.

Child: 10-14 yr: 6.25 mg at the start of the symptoms. >14 yr: follow adult dose.

Oral

Nausea and vomiting

Adult: As hydrochloride: 25 or 50 mg tid.

Oral

Pruritic skin disorders

Adult: As hydrochloride: 25-50 mg daily.

Food(before/after)

Should be taken with food. (Take w/in ½ hr before meals.)

List of Contraindications

Buclizine and Pregnancy

Potentially Fatal: EffeCategory C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.ct of alcohol, sedatives and other CNS depressants potentiated.

Buclizine and Other Contraindications

Hypersensitivity; neonates.

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