Chlorothiazide information from DrugsUpdate
P - Caution when used during Pregnancy.
L - Caution when used during Lactation.
Chlorothiazide sodium is a diuretic used within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. It is also used as an antihypertensive.
Pharmacodynamics
Chlorothiazide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of sodium and chloride ions and consequently of water. It also reduces the glomerular filtration rate.
Pharmacokinetics
Chlorothiazide Indications / Chlorothiazide Uses
Orally used in the treatment of hypertension and oedema.
Chlorothiazide Adverse Reactions / Chlorothiazide Side Effects
Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia.
Precautions
Information Not Available.
Special Precautions
Fluid and electrolyte disturbances; hepatic cirrhosis; gout; DM. Elderly; severe heart failure; renal or hepatic impairment. When administered IV, ensure that extravasation does not occur. Monitor blood glucose concentrations in patients taking antidiabetics. Pregnancy and lactation.
Other Drug Interactions
Digitalis glycosides; drugs that prolong QT interval; other antihypertensives; competitive muscle relaxants; pressor amines; corticosteroids, corticotrophin; β2-agonists, α-blockers; ACE inhibitors; NSAIDs; alcohol, barbiturates; opioids; lithium; allopurinol; tetracyclines; carbenoxolone; hypoglycaemics.
Dosage
Food(before/after)
Should be taken with food.
List of Contraindications
Chlorothiazide and Pregnancy
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).
Chlorothiazide and Other Contraindications
Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia.
Follow us:
