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Benzathine benzylpenicillin information from DrugsUpdate  

See Available Brands of Benzathine benzylpenicillin in India

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Benzathine benzylpenicillin (rINN) is a form of penicillin also known as benzathine penicillin. It is slowly absorbed into the circulation, after intramuscular injection, and hydrolysed to benzylpenicillin in vivo. 

Pharmacodynamics

Benzathine benzylpenicillin has the same antimicrobial action as benzylpenicillin which exerts its bactericidal action on growing and dividing bacteria by inhibiting bacterial cell wall synthesis. IM admin results in a prolonged effect, but because of its relatively low blood concentrations, its use should be restricted to microorganisms that are highly susceptible to it.

Pharmacokinetics

Absorption: Forms a depot which is slowly released and hydrolysed to benzylpenicillin after IM admin.


Distribution: Poor penetration into CSF.


Excretion: Detected in the urine for up to 12 wk after a single dose.

Benzathine benzylpenicillin Indications / Benzathine benzylpenicillin Uses

In Syphilis, Treponemal infections, Streptococcal pharyngitis and in Primary prophylaxis of rheumatic fever.

Benzathine benzylpenicillin Adverse Reactions / Benzathine benzylpenicillin Side Effects

Hypersensitivity reactions including uticaria; fever; joint pains; rashes; angioedema; serum sickness-like reactions; haemolytic anaemia; interstitial nephritis; neutropenia; thrombocytopenia; CNS toxicity including convulsions; diarrhoea; antibiotic-associated colitis.


Potentially Fatal: Anaphylaxis.

Special Precautions

Very high doses in poor renal function (risk of neurotoxicity) or heart failure. Avoid contact, skin sensitization may occur. Monitor serum potassium concentration, renal and haematological status. Spirochete infections particularly syphilis; suprainfection with penicillin-resistant organisms with prolonged use; avoid intrathecal route.

Other Drug Interactions

Probenecid prolongs T1/2 of benzathine benzylpenicillin. Bacteriostatic drugs e.g. chloramphenicol, tetracyclines; other antibacterials; anticoagulants.

Other Interactions

Information Not Available

Dosage

Intramuscular


Syphilis


Adult: Early syphilis: A single dose of 1.8 g, usually as 2 inj in separate sites. Late syphilis: 1.8 g at wkly intervals for 3 consecutive wk.


Intramuscular


Treponemal infections


Adult: 900 mg as a single dose.


Child: 450 mg as a single dose. 


Intramuscular


Streptococcal pharyngitis


Adult: 900 mg as a single dose. To prevent recurrences of acute rheumatic fever: 900 mg every 3-4 wk.


Child: <30 kg: 225-675 mg as a single dose. To prevent recurrences of acute rheumatic fever: <30 kg: 450 mg every 3-4 wk.


Intramuscular


Primary prophylaxis of rheumatic fever


Adult: 900 mg as a single dose. To prevent recurrences of acute rheumatic fever: 900 mg every 3-4 wk.


Child: <30 kg: 225-675 mg as a single dose. To prevent recurrences of acute rheumatic fever: <30 kg: 450 mg every 3-4 wk.


Intramuscular


Congenital syphilis


Child: Infants up to 2 yr: 37.5 mg/kg/day as a single dose.

Food(before/after)

Information Not Available

List of Contraindications

Benzathine benzylpenicillin and Pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Benzathine benzylpenicillin and Lactation

Information Not Available

Benzathine benzylpenicillin and Children

Information Not Available

Benzathine benzylpenicillin and Geriatic

Information Not Available

Benzathine benzylpenicillin and Other Contraindications

Information Not Available

Storage

Information Not Available

Lab interference

Information Not Available

Benzathine benzylpenicillin brands in India:

Longacillin Pencom Pencom-LA Penidure LA12 Penidure LA24 Penidure LA6

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