Basiliximab information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during Lactation
Basiliximab is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells.It is used to prevent rejection in organ transplantation, especially in kidney transplants.
Pharmacodynamics
Basiliximab, a chimeric murine/human monoclonal antibody, blocks the α-chain of the interleukin-2 receptor complex on the surface of activated T-lymphocytes.
Pharmacokinetics
Duration: 36 days.
Excretion: Terminal half-life: 7 days (adult) and 9 days (children).
Basiliximab Indications / Basiliximab Uses
Prophylaxis of acute graft rejection in renal transplantation (Intravenous)
Basiliximab Adverse Reactions / Basiliximab Side Effects
Peripheral oedema, hypertension, atrial fibrillation; fever, headache, insomnia, pain; wound complication, acne; hypokalaemia, hyperglycaemia, hyperuricaemia, hypophosphataemia, hypercholesterolaemia; GI effects; UTI; anaemia; tremor; dyspnoea, infection. Rarely, hypersensitivity and anaphylactoid-type reactions.
Precautions
Information Not Available
Special Precautions
Pregnancy and lactation. Re-exposure to a subsequent course of therapy of basiliximab
Other Drug Interactions
Immunosuppressives other than ciclosporin and corticosteroids may increase the potential for over-immunosuppression
Other Interactions
Information Not Available
Dosage
Intravenous
Prophylaxis of acute graft rejection in renal transplantation
Adult: 20 mg dose given by IV bolus or infusion over 20-30 min within 2 hr prior to transplantation surgery. Repeat once 4 days later. Withhold 2nd dose if graft loss or severe hypersensitivity reaction occurs.
Child: <35 kg: 10 mg dose 2 hr before surgery, repeated once 4 days later; ≥35 kg: same as adult dosing. Withhold 2nd dose if graft loss or severe hypersensitivity reaction occurs.
Food(before/after)
Information Not Available
List of Contraindications
Basiliximab and Pregnancy
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Basiliximab and Lactation
Caution when used during lactation
Basiliximab and Children
Information Not Available
Basiliximab and Geriatic
Information Not Available
Basiliximab and Other Contraindications
Hypersensitivity to basiliximab and murine proteins
Storage
Information Not Available
Lab interference
Information Not Available
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