Bacitracin information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during Lactation
Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis.
Pharmacodynamics
Bacitracin prevents transfer of mucopeptides into the growing cell wall thus inhibiting bacterial cell wall synthesis.
Pharmacokinetics
Duration: 6-8 hr.
Absorption: Not well absorbed from the GI tract.
Excretion: About 10-40% of a single injected dose is excreted in the urine within 24 hr.
Bacitracin Indications / Bacitracin Uses
In Vancomycin-resistant enterococci infections (orally), in Clostridium difficile-associated diarrhoea and colitis (orally), in Staphylococcal infections (i.m) and in Local infections (topical/cutaneous).
Bacitracin Adverse Reactions / Bacitracin Side Effects
Systemic admin: Nausea, vomiting, hypersensitivity reactions, severe nephrotoxicity, inj site pain.
Precautions
Information Not Available
Special Precautions
Pregnancy, lactation, Avoid prolonged use. IM use may cause renal failure. Do not admin IV (severe thrombophloebitis)
Other Drug Interactions
Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents.
Other Interactions
Information Not Available
Dosage
Oral
Vancomycin-resistant enterococci infections
Adult: 20,000-25,000 u every 6 hr for 7-10 days.
Oral
Clostridium difficile-associated diarrhoea and colitis
Adult: 20,000-25,000 u every 6 hr for 7-10 days.
Intramuscular
Staphylococcal infections
Adult: 10,000-25,000 u every 6 hr. Max: 100,000 u/day and 25,000 u/dose.
Child: Infant >2.5 kg: 1000 u/kg daily in 2-3 div doses; <2.5 kg: 900 u/kg daily in 2 or 3 div doses. Do not admin for >12 days.
Topical/Cutaneous
Local infections
Adult: In combination with neomycin: Apply once or thrice daily, as directed.
Incompatibility: Incompatible in bases containing stearyl alcohol, cholesterol, polyoxyethylene derivatives and sodium laurilsulfate. Rapidly inactivated in bases containing water, macrogols, propylene glycol, glycerol, cetylpyridinium chloride, benzalkonium chloride, ichthammol, phenol and tannic acid.
Food(before/after)
Information Not Available
List of Contraindications
Bacitracin and Pregnancy
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Bacitracin and Lactation
Caution when used during Lactation
Bacitracin and Children
Information Not Available
Bacitracin and Geriatic
Information Not Available
Bacitracin and Other Contraindications
Hypersensitivity; renal impairment
Storage
Information Not Available
Lab interference
Information Not Available
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