Ceftriaxone + Sulbactam information from DrugsUpdate
Ceftriaxone is a broad-spectrum semi-synthetic third-generation cephalosporin with a potent bactericidal activity against a wide range of gram-positive and gram-negative bacteria. Sulbactam is ß– lactamase inhibitor.
Pharmacodynamics
Pharmacokinetics
Information Not Available
Ceftriaxone + Sulbactam Indications / Ceftriaxone + Sulbactam Uses
Infections caused by pathogens sensitive to Ceftriaxone Injection, e.g.:
- sepsis;
- meningitis;
- abdominal infections (peritonitis, infections of the biliary and gastrointestinal tracts);
- infections of the bones, joints, soft tissue, skin and of wounds;
- infections in patients with impaired defence mechanisms;
- renal and urinary tract infections;
- respiratory tract infections, particularly pneumonia, and ear, nose and throat infections;
- genital infections, including gonorrhoea.
Perioperative prophylaxis of infections.
Ceftriaxone + Sulbactam Adverse Reactions / Ceftriaxone + Sulbactam Side Effects
Information Not Available
Precautions
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Special Precautions
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Other Drug Interactions
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Other Interactions
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Dosage
The recommended adult dosage is 1.5 g (1 g Ceftriaxone as the sodium salt plus 0.5 g sulbactam as the sodium salt) to 3 g (2 g Ceftriaxone as the sodium salt plus 1 g sulbactam as the sodium salt) every six hours. This 1.5 to 3 g range represents the total of Ceftriaxone content plus the sulbactam content and corresponds to a range of 1 g Ceftriaxone /0.5 g sulbactam to 2 g Ceftriaxone /1 g sulbactam. The total dose of sulbactam should not exceed 4 grams per day.
Neonates, infants and children up to 12 years:
The following dosage schedules are recommended for once daily administration. Neonates (up to 14 days): 20 to 50 mg/kg bodyweight once daily. The daily dose should not exceed 50 mg/kg. It is not necessary to differentiate between premature and term infants. Infants and children (15 days to 12 years): 20 to 80 mg/kg once daily. For children with bodyweights of 50 kg or more, the usual adult dosage should be used. Intravenous doses of NLT 50 mg/kg bodyweight should be given by infusion over at least 30 minutes.
Food(before/after)
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List of Contraindications
Ceftriaxone + Sulbactam and Pregnancy
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Ceftriaxone + Sulbactam and Lactation
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Ceftriaxone + Sulbactam and Children
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Ceftriaxone + Sulbactam and Geriatic
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Ceftriaxone + Sulbactam and Other Contraindications
Ceftriaxone Injection is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics. In patients hypersensitive to penicillin, consider the possibility of allergic cross-reactions.
The use of sulbactam is contraindicated in individuals with a history of hypersensitivity reactions to any of the penicillins.
Storage
Information Not Available
Lab interference
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