Fluorometholone information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
Fluorometholone is a corticosteroid, most often used after laser-based refractive surgery. Fluorometholone acetate ophthalmic suspension is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
Pharmacodynamics
Fluorometholone suppresses the migration of polymorphonuclear leukocytes and reversal of increased capillary permeability thus decreasing inflammation.
Pharmacokinetics
Absorption: Into aqueous humor; slight systemic absorption.
Fluorometholone Indications / Fluorometholone Uses
Ophthalmic
Allergic and inflammatory conditions of the eye.
Fluorometholone Adverse Reactions / Fluorometholone Side Effects
Elevated intraocular pressure, optic nerve damage, postsubcapsular cataract formation, delayed wound healing, uveitis, perforation of the globe, keratitis, conjunctivitis, corneal ulcers, loss of accommodation, secondary ocular infections, rarely systemic hypercorticoidism.
Precautions
Glaucoma (check intraocular pressure periodically), history of herpes simplex fungal or bacterial infections. Not to be used in mustard gas keratitis and Sjogren's keratoconjunctivitis. May cause corneal and scleral thinning which may lead to perforation in serious cases. Use of steroids after cataract surgery may prolong healing time and increase bleb formation. Pregnancy, lactation; children <2 yr.
Special Precautions
Information Not Available
Other Drug Interactions
Information Not Available
Other Interactions
Information Not Available
Dosage
Adult: As 0.1% ointment: Apply 1/2 inch ribbon to the conjunctival sac 1-3 times daily. As 0.1% solution: Instil 1-2 drops into the conjunctival sac 2-4 times daily. Dosage may be increased to every 4 hr in severe cases during the initial 24-48 hr. Re-evaluate if no signs of improvement after 48 hr of treatment.
Child: >2 yr: As 0.1% ointment: Apply 1/2 inch ribbon to the conjunctival sac 1-3 times daily. As 0.1% solution: Instil 1-2 drops into the conjunctival sac 2-4 times daily. Dosage may be increased to every 4 hr in severe cases during the initial 24-48 hr. Re-evaluate if no signs of improvement after 48 hr of treatment.
Food(before/after)
Information Not Available
List of Contraindications
Fluorometholone and Pregnancy
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Fluorometholone and Lactation
Information Not Available
Fluorometholone and Children
Information Not Available
Fluorometholone and Other Contraindications
Viral diseases of the cornea and conjunctiva, including epithelial herpes simplex keratitis (dendritic keratitis), Vaccinia and Varicella, mycobacterial eye infection, ocular fungal infections, untreated eye infections; hypersensitivity.
Storage
Ophthalmic: Store below 25°C
Lab interference
Ophthalmic: Store below 25°C
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