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Betamethasone dipropionate + Clotrimazole information from DrugsUpdate  

See Available Brands of Betamethasone dipropionate + Clotrimazole in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Clotrimazole; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
Clotrimazole; Belongs to the class of imidazole and triazole derivatives for topical use. Used in the treatment of fungal infection.
Clotrimazole; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.

Pharmacodynamics

Betamethasone dipropionate is a corticosteroid that prevents and reduce inflammation by depressing the migration of polymorphonuclear leukocytes and fibroblasts; reversing capillary permeability and lysosomal stabilisation at the cellular level. Clotrimazole is an antifungal agent that binds to phospholipids in the fungal cell membrane. It causes loss of essential intracellular components by altering cell wall permeability.

Pharmacokinetics

Absorption: Betamethasone dipropionate: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier.
Distribution: Betamethasone dipropionate: Once absorbed systemically, it is bound to plasma proteins in varying extents.
Metabolism: Betamethasone dipropionate: Once absorbed through the skin, it is metabolised mainly by the liver.
Excretion: Betamethasone dipropionate: Once absorbed through the skin, it is excreted largely renally; may also be excreted via the bile.

Betamethasone dipropionate + Clotrimazole Indications / Betamethasone dipropionate + Clotrimazole Uses

Information Not Available

Betamethasone dipropionate + Clotrimazole Adverse Reactions / Betamethasone dipropionate + Clotrimazole Side Effects

Dry skin, burning sensation at the site of application, paresthesia, oedema, rash, secondary infections, stinging, skin atrophy.

Precautions

Information Not Available

Special Precautions

Systemic absorption of betamethasone may result in suppression of the hypothalmic-pituitary-adrenal axis; prolonged or excessive use may increase systemic absorption of the drug. Monitor for signs of infection. Safety and efficacy have not been established in children <17 yr. Elderly. Pregnancy and lactation.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Topical/Cutaneous
Inflammed tinea pedis, tinea cruris and tinea corporis
Adult: ≥17 yr: As cream/lotion (per g containing clotrimazole 10 mg and betamethasone dipropionate 0.64 mg): Apply onto the affected area(s) bid. Recommended treatment duration: Up to 2 wk (tinea corporis and tinea cruris) and 4 wk (tinea pedis). Max: 45 g/wk.

Food(before/after)

Information Not Available

List of Contraindications

Betamethasone dipropionate + Clotrimazole and Pregnancy

Caution when used pregnancy

Betamethasone dipropionate + Clotrimazole and Lactation

Caution when used during lactation

Betamethasone dipropionate + Clotrimazole and Geriatic

Information Not Available

Betamethasone dipropionate + Clotrimazole and Other Contraindications

Hypersensitivity

Storage

Topical/Cutaneous: Store at 25°C

Lab interference

Topical/Cutaneous: Store at 25°C

Betamethasone dipropionate + Clotrimazole brands in India:

Candigen-BG Epicort-GC Lotriderm Propyzole-E Statum Plus Statum-B Statum-B Lotion

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