Betamethasone dipropionate + Clotrimazole information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
Clotrimazole; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.
Clotrimazole; Belongs to the class of imidazole and triazole derivatives for topical use. Used in the treatment of fungal infection.
Clotrimazole; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.
Pharmacodynamics
Betamethasone dipropionate is a corticosteroid that prevents and reduce inflammation by depressing the migration of polymorphonuclear leukocytes and fibroblasts; reversing capillary permeability and lysosomal stabilisation at the cellular level. Clotrimazole is an antifungal agent that binds to phospholipids in the fungal cell membrane. It causes loss of essential intracellular components by altering cell wall permeability.
Pharmacokinetics
Absorption: Betamethasone dipropionate: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier.
Distribution: Betamethasone dipropionate: Once absorbed systemically, it is bound to plasma proteins in varying extents.
Metabolism: Betamethasone dipropionate: Once absorbed through the skin, it is metabolised mainly by the liver.
Excretion: Betamethasone dipropionate: Once absorbed through the skin, it is excreted largely renally; may also be excreted via the bile.
Betamethasone dipropionate + Clotrimazole Indications / Betamethasone dipropionate + Clotrimazole Uses
Information Not Available
Betamethasone dipropionate + Clotrimazole Adverse Reactions / Betamethasone dipropionate + Clotrimazole Side Effects
Dry skin, burning sensation at the site of application, paresthesia, oedema, rash, secondary infections, stinging, skin atrophy.
Precautions
Information Not Available
Special Precautions
Systemic absorption of betamethasone may result in suppression of the hypothalmic-pituitary-adrenal axis; prolonged or excessive use may increase systemic absorption of the drug. Monitor for signs of infection. Safety and efficacy have not been established in children <17 yr. Elderly. Pregnancy and lactation.
Other Drug Interactions
Information Not Available
Other Interactions
Information Not Available
Dosage
Topical/Cutaneous
Inflammed tinea pedis, tinea cruris and tinea corporis
Adult: ≥17 yr: As cream/lotion (per g containing clotrimazole 10 mg and betamethasone dipropionate 0.64 mg): Apply onto the affected area(s) bid. Recommended treatment duration: Up to 2 wk (tinea corporis and tinea cruris) and 4 wk (tinea pedis). Max: 45 g/wk.
Food(before/after)
Information Not Available
List of Contraindications
Betamethasone dipropionate + Clotrimazole and Pregnancy
Caution when used pregnancy
Betamethasone dipropionate + Clotrimazole and Lactation
Caution when used during lactation
Betamethasone dipropionate + Clotrimazole and Geriatic
Information Not Available
Betamethasone dipropionate + Clotrimazole and Other Contraindications
Hypersensitivity
Storage
Topical/Cutaneous: Store at 25°C
Lab interference
Topical/Cutaneous: Store at 25°C
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