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Amlodipine + Benazepril information from DrugsUpdate  

See Available Brands of Amlodipine + Benazepril in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Amlodipine; Belongs to the class of selective dihydropyridine derivative calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Benazepril; Belongs to the class of ACE inhibitors. Used in the treatment of cardiovascular disease.

Pharmacodynamics

Amlodipine is a dihydropyridine calcium antagonist that lowers BP by relaxing the coronary vascular smooth muscles and producing coronary vasodilation; it does this by inhibiting the entry of Ca ions into the 'slow channels' or voltage-sensitive areas of the vascular smooth muscle and myocardium during depolarisation. Benazepril and its active metabolite benazeprilat inhibit ACE, which results in decreased plasma angiotensin II and decreased aldosterone secretion.

Pharmacokinetics

Absorption: Absorption after oral admin: 64-90% (amlodipine) and at least 37% (benazepril).
Distribution: Protein binding: 93% (amlodipine).
Metabolism: Benazepril: Almost completely metabolised to benazeprilat mainly in the liver. Amlodipine: Largely metabolised in liver.
Excretion: Amlodipine: 10% of parent compound and 60% of the metabolites are removed in urine. Benazeprilate: Mainly removed renally. Elimination half life: 10-11 hr (benazeprilat); about 2 days (amlodipine).

Amlodipine + Benazepril Indications / Amlodipine + Benazepril Uses

Information Not Available

Amlodipine + Benazepril Adverse Reactions / Amlodipine + Benazepril Side Effects

Cough, flushing, headache, peripheral oedema, cough, diarrhoea, dizziness, oedema, fainting, fatigue, fever, flushing, hyperkalaemia, hypotension, musculoskeletal pain, loss of taste, nausea, palpitations, skin rash, somnolence, acute renal disease, agranulocytosis, bone marrow suppression, angina pectoris, bradycardia, chest pain, haemolytic anaemia, hepatotoxicity, laryngeal oedema, neutropenia, orthostatic hypotension, pancreatitis, pemphigus, thrombocytopenia.
Potentially Fatal: Hypersensitivity, angioedema & Stevens-Johnson syndrome.

Precautions

Information Not Available

Special Precautions

Elderly, impaired renal and hepatic function, CHF, children, low salt diet, aortic stenosis, myocardial ischaemia, angina pectoris, cholestatic jaundice, allergic angioedema, hyperkalaemia, cerebrovascular insufficiency, coronary insufficiency, bone marrow depression, autoimmune disease, use before,during or immedediately after magor operation. Discontinue treatment if patients develop jaundice or marked elevations of hepatic enzymes.

Other Drug Interactions

NSAIDs decreases effect of ACE inhibitors. Concurrent admin with diuretics may increase the hypotensive effect. Increased risk of hypotension with cytochrome P450 inhibitors such as protease inhibitors, azole antifungals (eg itraconazole). Reduced hypotensive effect if used with cytochrome P450 inducers such as phenobarbital, rifmapicin & St John's Wort.Concurrent use with lithium may increase serum levels of lithium and risk of lithium toxicity.
Potentially Fatal: Increased risk of hyperkalaemia when used with potassium supplements or potassium-sparing diuretics. Increased risk of leukocytopenia when used with allopurinol or interferons.

Other Interactions

Information Not Available

Dosage

Oral
Hypertension
Adult: As capsules containing amlodipine (mg)/benazepril HCl (mg): 2.5/10, 5/10, 5/20, 5/40, 10/20, 10/40. Amlodipine component: 2.5-10 mg once daily (max: 10 mg/day); benazepril component: 10-40 mg once daily. (Max: 40 mg/day)
Elderly: As capsules containing amlodipine (mg)/benazepril HCl (mg): 2.5/10, 5/10, 5/20, 5/40, 10/20, 10/40. Initiate with 2.5 mg amlodipine per day.

Food(before/after)

Information Not Available

List of Contraindications

Amlodipine + Benazepril and Pregnancy

Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Amlodipine + Benazepril and Lactation

Contraindicated in lactation

Amlodipine + Benazepril and Children

Information Not Available

Amlodipine + Benazepril and Geriatic

Information Not Available

Amlodipine + Benazepril and Other Contraindications

Hypersensitivity, pregnancy, lactation

Storage

Oral: Store at 25°C

Lab interference

Oral: Store at 25°C

Amlodipine + Benazepril brands in India:

Amace-BP Amlo-B

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