Norfloxacin + Tinidazole information from DrugsUpdate
Norfloxacin; Belongs to the class of quinolones, fluoroquinolone. Used in the treatment of systemic infections.
Tinidazole; Belongs to the class of imidazole derivative antibacterials. Used in the treatment of systemic infections.
tinidazole; Belongs to the class of nitroimidazole derivatives antiprotozoals. Used in the treatment amoebiasis and other protozoal diseases.
norfloxacin; Belongs to the class of other antiinfectives. Used in the treatment of eye infections.
Pharmacodynamics
Tinidazole is active against protozoa and anaerobic bacterial infections against which norfloxacin is inactive. The combination of norfloxacin and tinidazole has an extended range of antimicrobial spectrum and is effective in mixed gut infections, diarrhoeas and dysentery.
Pharmacokinetics
Information Not Available
Norfloxacin + Tinidazole Indications / Norfloxacin + Tinidazole Uses
Information Not Available
Norfloxacin + Tinidazole Adverse Reactions / Norfloxacin + Tinidazole Side Effects
Nausea, vomiting, heartburn, metallic taste, headache, dizziness, depression, insomnia, rash, dry mouth, fever, arthralgia. Rarely eosinophilia, bone marrow depression.
Potentially Fatal: Rarely hypersensitivity reactions, facial and laryngeal oedema, hypotension, bronchospasm.
Special Precautions
Moderate renal impairment, history of or susceptibility to seizures, alcohol intake. Ensure adequate hydration and urine output.
Other Drug Interactions
Antacids reduce absorption of norfloxacin from gut. Probenecid reduces urinary excretion of norfloxacin.
Potentially Fatal: Increased levels of theophylline and ciclosporin, warfarin effects potentiated, disulfiram-like reactions with alcohol.
Other Interactions
Food interactions: Reduced absorption of norfloxacin esp with milk or yogurt.
Dosage
Oral
Diarrhoea and dysentery of amoebic, bacterial or mixed origins
Adult: Per tablet contains norfloxacin 400 mg and tinidazole 600 mg: 1 tablet bid for 5 days.
Food(before/after)
Information Not Available
List of Contraindications
Norfloxacin + Tinidazole and Pregnancy
Information Not Available
Norfloxacin + Tinidazole and Lactation
Information Not Available
Norfloxacin + Tinidazole and Children
Information Not Available
Norfloxacin + Tinidazole and Geriatic
Information Not Available
Norfloxacin + Tinidazole and Other Contraindications
Hypersensitivity, neurological disorders including convulsions, blood dyscrasias, children. Pregnancy and lactation.
Storage
Information Not Available
Lab interference
Information Not Available
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