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Betamethasone + Neomycin information from DrugsUpdate  

See Available Brands of Betamethasone + Neomycin in India

Betamethasone belongs to the class of corticosteroids. This combined drugs mainly used as topical anti-infectives, in intestinal inflammation and incorticosteroid-responsive dermatoses with secondary infection.


Pharmacodynamics

Betamethasone valerate is a corticosteroid which is effective in inflammatory dermatoses. It is also effective in less responsive conditions such as psoriasis. Neomycin sulfate is a broad spectrum antibiotic. It is bactericidal against many bacteria which are commonly associated with skin infections.

Pharmacokinetics

Absorption: Betamethasone: Absorption through the skin depends on several factors e.g. presence of occlusive dressing, integrity of the epidermal barrier.
Distribution: Betamethasone: Bound to plasma proteins to varying extent.
Metabolism: Betamethasone: Largely metabolised hepatically.
Excretion: Betamethasone: Mainly excreted via the kidneys.

Betamethasone + Neomycin Indications / Betamethasone + Neomycin Uses

Information Not Available

Betamethasone + Neomycin Adverse Reactions / Betamethasone + Neomycin Side Effects

Prolonged use may cause local atrophic changes in the skin e.g. thining, striae and dilatation of superficial blood vessels. Local skin burning sensation, pruritus, pigmentation changes, allergic contact dermatitis and hypertrichosis. Ophthalmic preparation: Corneal ulceration, increased intraocular pressure, mydriasis, ptosis, epithelial punctate keratitis.

Precautions

Information Not Available

Special Precautions

Avoid prolonged treatment as it may lead to systemic corticosteroid effects even withour occlusion. Avoid prolonged excessive application to the facial areas. Withdraw treatment if there is spread of the infection. Risk of glaucoma development if preparation enters eye(s). Regular monitoring is recommended when used in psoriasis due to treatment tolerance, rebound relapses, generalised pustular psoriasis or systemic toxicity. Increased risk of contact sensitisation when used for extended period or recurrently. Pregnancy and lactation. Ophthalmic preparation: Monitor intraocular pressure, cataract formation of unsuspected infections; evaluate treatment if there is no clinical improvement after 7 days. Not to be used for undiagnosed red eye.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: As ophthalmic ointment containing betamethasone sodium phosphate 0.1% w/w and neomycin sulfate 0.5% w/w: Apply ¼ inch long to the lower eye lid 2-3 times daily and/or at night. Usual treatment duration: Up to 7 days/course.
Topical/Cutaneous
Corticosteriod-responsive dermatoses with secondary infection
Adult: As cream/ointment containing betamethasone (as valerate) 0.122% w/w and neomycin sulfate 0.5% w/w: Apply onto the affected area(s) 2-3 times daily.
Child: ≥2 yr: As cream/ointment containing betamethasone (as valerate) 0.122% w/w and neomycin sulfate 0.5% w/w: Apply onto the affected area(s) 2-3 times daily. Usual treatment duration: Up to 5 days/course.
Renal impairment: Dose reduction may be necessary.

Food(before/after)

Information Not Available

List of Contraindications

Betamethasone + Neomycin and Pregnancy

Information Not Available

Betamethasone + Neomycin and Lactation

Information Not Available

Betamethasone + Neomycin and Children

Information Not Available

Betamethasone + Neomycin and Geriatic

Information Not Available

Betamethasone + Neomycin and Other Contraindications

Hypersensitivity. Rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus and primary cutaneous viral infections. Not to be used in otitis externa complicated by ear-drum perforation. Treatment of primary infected skin lesions caused by fungi or bacteria; primary or secondary infections due to yeast; or secondary infections due to Pseudomonas or Proteus species. Children <2 yr. Ophthalmic preparation: Not to be used in patients with glaucoma or herpetic keratitis.

Storage

Ophthalmic: Store <25°C. Topical/Cutaneous: Store <25°C

Lab interference

Ophthalmic: Store <25°C. Topical/Cutaneous: Store <25°C

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