Nadroparin Calcium information from DrugsUpdate
P - Caution when used during pregnancy
L - Contraindicated in lactation
FI - Food *
Nadroparin is a form of low molecular weight heparin.
Pharmacodynamics
Pharmacokinetics
Nadroparin possesses high anti-factor Xa activity but has low anti-factor IIa (antithrombin) activity, potentially providing equivalent antithrombotic efficacy with less bleeding complications.
Duration: 18 hours.
Absorption: ≥89% of dose is absorbed (subcutaneous). Peak plasma concentrations in 3-5 hours.
Excretion: Via urine. Elimination half-life: 3.5 hr; prolonged to 6 hr in renal impairment.
Nadroparin Calcium Indications / Nadroparin Calcium Uses
Information Not Available
Nadroparin Calcium Adverse Reactions / Nadroparin Calcium Side Effects
Hypoaldosteronism; bleeding, thrombocytopenia; rash; haematoma and pain at inj site; allergic reactions; osteopaenic effects; increased ALT/AST.
Precautions
Information Not Available
Special Precautions
Patients with recent or anticipated neuraxial anaesthesia; history of heparin-induced thrombocytopenia, congenital or drug-induced thrombocytopenia or platelet defects; patients at increased risk of bleeding; severe hepatic or renal disease. Monitor for signs of bleeding; hyperkalaemia. Pregnancy.
Other Drug Interactions
Increased risk of bleeding with thrombolytic agents, oral anticoagulants and antiplatelet drugs.
Other Interactions
Food Interaction
Additive anticoagulant or antiplatelet effects may occur with cat's claw, dong quai, evening primrose, garlic and ginseng.
Dosage
Subcutaneous
Prophylaxis of venous thromboembolism during surgical procedures
Adult: Moderate-risk patients: 2850 units daily for 7 days or until the patient is ambulant; give the 1st dose 2-4 hr before surgery. High-risk patients: 38 units/kg 12 hr before surgery, 12 hr post-operatively and then daily until 3 days after surgery; increase dose by 50% to 57 units/kg daily. Total duration of treatment: At least 10 days.
Renal impairment: Moderate to severe: Dose reduction may be required.
Subcutaneous
Thromboembolic disorders
Adult: 85 units/kg every 12 hr for up to 10 days or 171 units/kg/day once daily.
Renal impairment: Moderate to severe: Dose reduction may be required.
Parenteral
Unstable angina
Adult: 86 units/kg SC every 12 hr for about 6 days. An initial dose of 86 units/kg may be given IV. Low-dose aspirin should also be given.
Renal impairment: Dose reduction may be required.
Intra-arterial
Prevention of clotting in the extracorporeal circulation during haemodialysis sessions of <4 hr
Adult: <50 kg: 2850 units; 50-69 kg: 3800 units; ≥70 kg: 5700 units. Administer in the arterial line of the circuit at the start of dialysis. Patients at high risk of haemorrhage: Reduce dose.
Food(before/after)
Information Not Available
List of Contraindications
Nadroparin Calcium and Pregnancy
Caution when used during pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).
Nadroparin Calcium and Lactation
Contraindicated in lactation
Nadroparin Calcium and Children
Information Not Available
Nadroparin Calcium and Geriatic
Information Not Available
Nadroparin Calcium and Other Contraindications
Acute infective endocarditis; haemorrhage or haemostasis disorder; active peptic ulceration; haemorrhagic cerebrovascular event; severe uncontrolled hypertension; diabetic or haemorrhagic retinopathy; injuries to or operations on the CNS, eyes or ears; history of thrombocytopenia with nadroparin. Lactation. Not for IM admin.
Storage
Intra-arterial
Store at 15-30°C (59-86°F). Do not freeze or refrigerate.
Parenteral
Store at 15-30°C (59-86°F). Do not freeze or refrigerate.
Subcutaneous
Store at 15-30°C (59-86°F). Do not freeze or refrigerate.
Lab interference
Intra-arterial
Store at 15-30°C (59-86°F). Do not freeze or refrigerate.
Parenteral
Store at 15-30°C (59-86°F). Do not freeze or refrigerate.
Subcutaneous
Store at 15-30°C (59-86°F). Do not freeze or refrigerate.
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