Drotaverine information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
Drotaverine is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.
A small 2003 study found drotaverine to be nearly 80% effective in treating renal colic. It has also been used to accelerate labor.
Pharmacodynamics
Pharmacokinetics
Drotaverine has antispasmodic effect mediated via inhibition of phosphodiesterase-IV, specific for smooth muscle. It has a rapid and direct action on the smooth muscle. It acts to correct cyclic AMP and Ca imbalance at the spastic site, thereby relieving smooth muscle spasm and pain.
Drotaverine Indications / Drotaverine Uses
Information Not Available
Drotaverine Adverse Reactions / Drotaverine Side Effects
Vertigo, nausea, vomiting, dry mouth
Precautions
Information Not Available
Special Precautions
Exercise caution in patients with renal/hepatic/cardiac dysfunction. Pregnacy, lactation.
Other Drug Interactions
May attenuate the action of levodopa. Concurrent use of analgesics, antimuscarinics or benzodiazepines. Additive beneficial effect with concurrent use of analgesics, antimuscarinics or benzodiazepines.
Other Interactions
Information Not Available
Dosage
Oral
Antispasmodic
Adult: 40-80 mg tid.
Child: 1-6 yr: 20 mg 3-4 times daiily; >6 yr: 40 mg tid.
Food(before/after)
May be taken with or without food
List of Contraindications
Drotaverine and Pregnancy
Caution when used during pregnancy
Drotaverine and Lactation
Caution when used during lactation
Drotaverine and Children
Information Not Available
Drotaverine and Geriatic
Information Not Available
Drotaverine and Other Contraindications
Severe renal/hepatic/cardiac dysfunction. Porphyria.
Storage
Information Not Available
Lab interference
Information Not Available
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