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Dobutamine information from DrugsUpdate  

See Available Brands of Dobutamine in India

P - Caution when used during pregnancy

Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system. Dobutamine was developed by a laboratory led by Drs. Ronald Tuttle and Jack Mills at Eli Lilly and Company, as a structural analogue of isoproterenol.

Pharmacodynamics

Pharmacokinetics

Intravenous
Acute heart failure
Adult: 2.5-10 mcg/kg, up to 0.5-40 mcg/kg according to patient's heart rate, cardiac output, BP and urine output.
Intravenous
Cardiac stress test
Adult: 5 mcg/kg/min for 8 min using a 1 mg/ml solution, dose is then increased at 5 mcg/kg/min until 20 mcg/kg/min, with each dose being infused for 8 min before the next increase. Monitor ECG and stop infusion if arrhythmias, marked ST segment depression or other adverse effects occur.

Dobutamine Indications / Dobutamine Uses

Information Not Available

Dobutamine Adverse Reactions / Dobutamine Side Effects

Increased heart rate and BP, ectopic beats, palpitation. Nausea, headache, chest pain, palpitation, dyspnoea, paraesthesia, leg cramps. Tissue necrosis at site of extravasation.
Potentially Fatal: Cardiac arrhythmias, allergy (rare), MI and hypotension.

Precautions

General
1.During the administration of Dobutamine Injection, USP, as with any adrenergic agent, ECG and blood pressure should be continuously monitored. In addition, pulmonary wedge pressure and cardiac output should be monitored whenever possible to aid in the safe and effective infusion of Dobutamine hydrochloride.
2.Hypovolemia should be corrected with suitable volume expanders before treatment with Dobutamine hydrochloride is instituted.
3.No improvement may be observed in the presence of marked mechanical obstruction, such as severe valvular aortic stenosis.
Usage Following Acute Myocardial Infarction − Clinical experience with Dobutamine hydrochloride following myocardial infarction has been insufficient to establish the safety of the drug for this use. There is concern that any agent that increases contractile force and heart rate may increase the size of an infarction by intensifying ischemia, but it is not known whether Dobutamine hydrochloride does so.

Special Precautions

Correct hypovolaemia prior to treatment. Increased risk of rapid ventricular response in patients with atrial fibrillation. Insufficient data to determine the safety and efficacy of dobutamine use after acute MI. Elderly. Neonates. Pregnancy.

Other Drug Interactions

Increased cardiac output when used with nitroprusside. Increased vasopressor effect of dobutamine when used with bretylium, guanethidine, oxytocic drugs or TCAs.

Other Interactions

Information Not Available

Dosage

Intravenous
Acute heart failure
Adult: 2.5-10 mcg/kg, up to 0.5-40 mcg/kg according to patient's heart rate, cardiac output, BP and urine output.
Intravenous
Cardiac stress test
Adult: 5 mcg/kg/min for 8 min using a 1 mg/ml solution, dose is then increased at 5 mcg/kg/min until 20 mcg/kg/min, with each dose being infused for 8 min before the next increase. Monitor ECG and stop infusion if arrhythmias, marked ST segment depression or other adverse effects occur.

Food(before/after)

Information Not Available

List of Contraindications

Dobutamine and Pregnancy

Caution when used during pregnancy

Dobutamine and Children

Information Not Available

Dobutamine and Geriatic

Information Not Available

Dobutamine and Other Contraindications

Hypersensitivity; idiopathic hypertrophic subaortic stenosis (IHSS).

Storage

Intravenous: Store at 15-30°C.

Lab interference

Intravenous: Store at 15-30°C.

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