Mecobalamin information from DrugsUpdate
LI - Lab *
Methylcobalamin is a cobalamin (MeB12) used in peripheral neuropathy, diabetic neuropathy etc. It is a form of vitamin B12. This vitamer is one of two active coenzymes used by B-12 dependent enzymes in the body, and is specifically the B-12 form used by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase.
Methylcobalamin is notable for being one of the few examples in nature of a bona fide organometallic bond. Methylcobalamin has been studied in conjunction with sleep-wake rhythm disorders, where it appears to yield benefits, but at a low or inconsistent level. It is used in treating diseases of vitamin B12 deficiency (such as pernicious anemia), or diseases of effective B12 deficiency, such as vitamin B12 metabolic pathway pathologies. One study suggests that once absorbed, methylcobalamin may be retained in the body better than cyanocobalamin.
Pharmacodynamics
Pharmacokinetics
Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.
Absorption
Peak plasma concentrations after 3 hr (oral); 0.9 hr (IM); 3 min (IV).
Excretion
Via urine.
Mecobalamin Indications / Mecobalamin Uses
Information Not Available
Mecobalamin Adverse Reactions / Mecobalamin Side Effects
Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site. Potentially Fatal: Anaphylactoid reactions (parenteral).
Precautions
Information Not Available
Special Precautions
Information Not Available
Other Drug Interactions
Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.
Other Interactions
Information Not Available
Dosage
Oral
Peripheral neuropathies Adult: 1500 mcg/day in 3 divided doses.
Parenteral
Peripheral neuropathies Adult: 500 mcg daily IM/IV 3 times/wk.
Parenteral
Megaloblastic anaemia caused by vitamin B12 deficiency Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.
Food(before/after)
May be taken with or without food
List of Contraindications
Mecobalamin and Pregnancy
Not contraindicated
Mecobalamin and Lactation
Not contraindicated
Mecobalamin and Children
Information Not Available
Mecobalamin and Geriatic
Information Not Available
Mecobalamin and Other Contraindications
Information Not Available
Storage
Oral
Store at room temperature. Protect from moisture and light. Parenteral: Store at room temperature. Do not expose to direct light.
Lab interference
Oral
Store at room temperature. Protect from moisture and light. Parenteral: Store at room temperature. Do not expose to direct light.
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