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Dicycloverine Hyrochoride information from DrugsUpdate  

3
See Available Brands of Dicycloverine Hyrochoride in India

P - Caution when used during pregnancy
L - Contraindicated in lactation

Dicyclomine is an anticholinergic that blocks muscarinic receptors. Dicyclomine is known as dicycloverine hydrochloride in the UK. Dicycloverine has 72 per cent of the anti-muscarinic power of atropine. It was invented in the United States in 1947.

Dicyclomine is used to treat intestinal hypermotility, the symptoms of Irritable Bowel Syndrome (IBS) (also known as spastic colon). It relieves muscle spasms and cramping in the gastrointestinal tract by blocking the activity of acetylcholine on cholinergic (or muscarinic) receptors on the surface of muscle cells. It is a smooth muscle relaxant.
In America, it is sold under the trade names: Bentyl, Byclomine, Dibent, Di-Spaz, Dilomine.
In the UK it is sold under the trade names: Merbentyl (containing 10mg dicycloverine) and Merbentyl 20 (containing 20mg dicycloverine).
It is also sold in the UK as part of a multi-ingredient preparation under the trade name Kolanticon (Peckforton Pharmaceuticals), which in addition to dicycloverine, contains an antiflatulent (simethicone) and two antacids (aluminium hydroxide and magnesium oxide).
It is sold under the trade names Bentylol (Hoechst Marion Roussel), Formulex (ICN), and Lomine (Riva) in Canada. it is sold under the trade names spasmo proxivon and spasmo plus in India.

Pharmacodynamics

Pharmacokinetics

Dicycloverine HCl relieves smooth muscle spasm in the GI and urinary tract. This effect is partly due to antimuscarinic action and partly direct action on the smooth muscle.

Dicycloverine Hyrochoride Indications / Dicycloverine Hyrochoride Uses

Information Not Available

Dicycloverine Hyrochoride Adverse Reactions / Dicycloverine Hyrochoride Side Effects

Difficulty in accommodation, exacerbation of glaucoma; tachycardia, palpitations, arrhythmias; urinary retention; restlessness; confusion, excitement, hallucination and delirium.
Potentially Fatal: Respiratory arrest in infants <10 wk.

Precautions

Overdosage:Symptoms: headache, dizziness, nausea, dry mouth, difficulty in swallowing, dilated pupils and hot dry skin. Management: treatment is symptomatic. Reduce drug absorption by emetics or gastric lavage.

Special Precautions

Hepatic or renal disease, urinary retention, paralytic ileus, hyperthyroidism, hypertension, congestive heart failure, cardiac tachyarrhythmia, children, elderly, pregnancy.

Other Drug Interactions

Antagonise the effect of drugs that affect GI motility e.g. metoclopramide. Absorption affected by concurrent admin with antacids.

Other Interactions

Information Not Available

Dosage

Oral
Gastrointestinal tract spasm
Adult: 10-20 mg tid.
Child: 2-12 yr: 10 mg tid; 6 mth-2 yr: 5-10 mg 3-4 times daily.
Elderly: Intramuscular
Gastrointestinal tract spasm
Adult: 20 mg 4 times a day given only for 1-2 days. Replace with oral therapy as soon as possible.

Food(before/after)

Dicycloverine: May be taken with or without food. (May be taken before or after meals.)

List of Contraindications

Dicycloverine Hyrochoride and Pregnancy

Caution when used during pregnancy

Dicycloverine Hyrochoride and Lactation

Contraindicated in lactation

Dicycloverine Hyrochoride and Children

Information Not Available

Dicycloverine Hyrochoride and Geriatic

Information Not Available

Dicycloverine Hyrochoride and Other Contraindications

Intestinal obstruction; intestinal atony; myasthenia gravis; glaucoma; reflux oesophagitis; infants <6 mth; lactation.

Storage

Intramuscular: Store below 30°C.
Oral: Store below 30°C.

Lab interference

Intramuscular: Store below 30°C.
Oral: Store below 30°C.

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