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Desloratadine information from DrugsUpdate  

See Available Brands of Desloratadine in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Desloratadine is a drug used to treat allergies. It is marketed under several trade names such as NeoClarityn, Claramax, Clarinex and Aerius. It is an active metabolite of loratadine, which is also on the market.



Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils.
Absorption: Peak plasma concentrations after 3 hr (oral).
Distribution: Protein-binding: 82-87%.
Metabolism: Hepatic; converted to 3-hydroxydesloratadine.
Excretion: Via urine and faeces (as metabolites).

Desloratadine Indications / Desloratadine Uses

Information Not Available

Desloratadine Adverse Reactions / Desloratadine Side Effects

Headache, fatigue, somnolence, dizziness; nausea, dyspepsia; xerostomia, dysmenorrhoea; pharyngitis.


Assess patient for allergy symptoms (eg, rhinitis, nasal congestion, sneezing, itching, watery eyes, hives) before starting therapy and periodically throughout therapy. Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy.
Overdosage:Treatment is symptomatic and supportive. Standard measures to reduce absorption to be adopted. Haemodialysis unlikely to be useful.

Special Precautions

Severe renal or hepatic failure; children <6 mth, elderly, epilepsy, pregnancy and lactation.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available


Allergic conditions
Adult: 5 mg once daily.
Child: ≥12 yr: 5 mg once daily; 6-11 yr: 2.5 mg; 1-5 yr: 1.25 mg; 6-11 mth: 1 mg. Doses to be taken once daily.
Renal impairment: Initially, 5 mg every other day.
Hepatic impairment: Initially, 5 mg every other day.


May be taken with or without food

List of Contraindications

Desloratadine and Pregnancy

Contraindicated in pregnancy.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Desloratadine and Lactation

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Contraindicated in lactation


Desloratadine and Children

Information Not Available

Desloratadine and Geriatic

Information Not Available

Desloratadine and Other Contraindications



Oral: Store below 30°C

Lab interference

Oral: Store below 30°C

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