logo image

Meclozine information from DrugsUpdate  

See Available Brands of Meclozine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Meclizine is an antihistamine considered to be an antiemetic. It is sold under the brand names of Bonine, Bonamine, Antivert, Postafen, and Dramamine (Less Drowsy Formulation), and is most commonly used to inhibit nausea and vomiting. Emesafene is a combination of meclizine (1/3) and pyridoxine (2/3). An alternative to dimenhydrinate (Dramamine, Gravol, Gravamin, and Vertirosan), meclizine is considered to be equally effective, but with reduced side effects. Note that in Canada, Antivert (no longer available) was a combination of meclizine and nicotinic acid.

Pharmacodynamics

Pharmacokinetics

Meclozine blocks vasopressor response to histamine and has a slight blocking action against acetylcholine. It decreases excitability of the middle ear labyrinth and blocks conduction in the middle ear vestibular-cerebellar pathways.


Onset About 1 hr (oral).


Duration 8-24 hr (oral).


Metabolism Hepatic.


Excretion Via urine (as metabolites); via faeces (as unchanged drug).

Meclozine Indications / Meclozine Uses

Information Not Available

Meclozine Adverse Reactions / Meclozine Side Effects

Drowsiness, thickening of bronchial secretions, dry mouth, fatigue, blurred vision.

Precautions

Information Not Available

Special Precautions

Angle-closure glaucoma, prostatic hyperplasia; pyloric or duodenal obstruction; asthma. Elderly. May affect the ability to drive or operate machinery. Pregnancy and lactation.

Other Drug Interactions

Additive effects with CNS depressants, neuroleptics, anticholinergics, alcohol.

Other Interactions

Information Not Available

Dosage

Oral Motion sickness Adult: 25-50 mg 1 hr before travelling and repeat every 24 hr if needed. Child: As hydrochloride: 2-6 yr: 6.25 mg once daily; 6-12 yr: 12.5 mg once daily; >12 yr: 25-50 mg 1 hr before traveling and repeat every 24 hr if needed. Oral Vertigo and vestibular disorders Adult: Up to 100 mg daily in divided doses.

Food(before/after)

Information Not Available

List of Contraindications

Meclozine and Pregnancy

Caution when used during pregnancy Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Meclozine and Lactation

Caution when used during lactation

Meclozine and Children

Information Not Available

Meclozine and Geriatic

Information Not Available

Meclozine and Other Contraindications

Information Not Available

Storage

Oral Conventional tablet: Store at 15-30 ℃ (59-86 °F). Chewable tablet: Store below 30℃ (86°F).

Lab interference

Oral Conventional tablet: Store at 15-30 ℃ (59-86 °F). Chewable tablet: Store below 30℃ (86°F).

Meclozine brands in India:

Diligan Diligan-25 PNV Pregnidoxin

© 2011-2020 DrugsUpdate.com from UPilot INC. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.