Cyproheptadine information from DrugsUpdate
P - Caution when used during pregnancy
L - Contraindicated in lactation
Cyproheptadine usually as cyproheptadine hydrochloride, trade name Periactin) is an antihistaminic/anticholinergic and antiserotonergic agent. It acts as a 5-HT2 receptor antagonist and also blocks calcium channels.
Pharmacodynamics
Pharmacokinetics
Cyproheptadine is a sedating antihistamine with antimuscarinic, serotonin-antagonist and calcium-channel blocking properties. It competes for H1-receptor sites on effector cells in the GIT, blood vessels and resp tract.
Absorption: Absorbed from the GIT (oral).
Metabolism: Completely hepatic.
Excretion: Via urine (as conjugates); via faeces.
Cyproheptadine Indications / Cyproheptadine Uses
Information Not Available
Cyproheptadine Adverse Reactions / Cyproheptadine Side Effects
Slight to moderate drowsiness, fatigue; dry mouth, GI upsets, nausea; appetite increase, wt gain and impaired alertness.
Precautions
General: Cyproheptadine has an atropine-like action and, therefore, should be used with caution in patients with:
History of bronchial asthma
Increased intraocular pressure
Hyperthyroidism
Cardiovascular disease
Hypertension
Special Precautions
Elderly; epilepsy; tasks requiring mental alertness; symptomatic prostate hypertrophy; epilepsy; alcoholism; pregnancy.
Other Drug Interactions
Masks ototoxicity produced by aminoglycosides and antibiotics.
Potentially Fatal: Potentiate CNS depressant actions of alcohol, barbiturates, sedatives, opioid analgesics and neuroleptics. Additive antimuscarinic action with MAOIs, atropine and tricyclic antidepressants.
Other Interactions
Information Not Available
Dosage
Oral
Allergic conditions
Adult: As HCl: 4 mg tid adjusted as necessary. Usual dose range: 12-16 mg daily in 3-4 divided doses. Up to 32 mg daily may be used in some cases.
Child: As HCl: 2-6 yr: 2 mg tid (max: 12 mg daily); 7-14 yr: 4 mg bid-tid (max: 16 mg daily).
Elderly:
Oral
Treatment and prophylaxis of migraine and other vascular headaches
Adult: As HCl: 4 mg, may repeat 30 minutes later. Not to exceed 8 mg within a 4-6-hr period. Maintenance dose: 4 mg every 4-6 hr.
Food(before/after)
May be taken with or without food. (May be taken w/ meals to reduce GI discomfort.)
List of Contraindications
Cyproheptadine and Pregnancy
Caution when used during pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters)
Cyproheptadine and Lactation
Contraindicated in lactation
Cyproheptadine and Children
Information Not Available
Cyproheptadine and Geriatic
Information Not Available
Cyproheptadine and Other Contraindications
Narrow-angle glaucoma; acute asthmatic attack; bladder neck obstruction; stenosing peptic ulcer; GIT obstruction; MAOIs therapy; hypersensitivity; neonates, lactation.
Storage
Oral: Store at 15-25°C
Lab interference
Oral: Store at 15-25°C
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