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Mebeverine information from DrugsUpdate  

See Available Brands of Mebeverine in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Mebeverine HCl is a musculotropic antispasmodic drug without atropic side-effects whose major therapeutic role is in the treatment of irritable bowel syndrome. It is also indicated for treatment of gastrointestinal spasm secondary to organic disorder. It was first registered in 1965. It is manufactured and marketed as Colofac, Duspatal and Duspatalin by Solvay Pharmaceuticals.

Pharmacodynamics

Pharmacokinetics

Mebeverine is an antispasmodic agent which exerts direct action on the GI smooth muscle.


Absorption


Rapidly absorbed from the GI tract (oral); peak plasma concentrations within 1-3 hr.


Distribution


Protein-binding: 75% to albumin.


Metabolism


Hydrolysed completely in the liver to veratric acid and mebeverine alcohol.


Excretion


Via urine (as metabolites).

Mebeverine Indications / Mebeverine Uses

Information Not Available

Mebeverine Adverse Reactions / Mebeverine Side Effects

GI disturbances, dizziness, headache, insomnia, anorexia, decreased heart rate, hypersensitivity reactions.

Precautions

After taking Colofac Tablets 135 mg, very rarely do, people taking this medicine may develop allergic reactions. These may include inflamed or reddened skin, itching or skin rashes.

Special Precautions

Severe hepatic or renal impairment; cardiac disorders e.g. heart block; porphyria. May impair ability to drive or operate machinery. Pregnancy and lactation.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Oral


Irritable bowel syndrome, Gastrointestinal tract spasm Adult: As hydrochloride: 135 mg tid or 100 mg tid. Modified-release preparation: 200 mg bid. As embonate: 150 mg tid. Child: As hydrochloride: 3-4 yr: 25 mg; 4-8 yr: 50 mg; 8-10 yr: 100 mg; >10 yr: 135-150 mg. All doses may be given tid. Modified-release preparation: Not recommended.

Food(before/after)

Should be taken with food. (Take immediately before or during meals.)

List of Contraindications

Mebeverine and Pregnancy

Caution when used during pregnancy

Mebeverine and Lactation

Caution when used during lactation

Mebeverine and Children

Information Not Available

Mebeverine and Geriatic

Information Not Available

Mebeverine and Other Contraindications

Paralytic ileus

Storage

Oral Conventional preparation: Store at or below 30 ℃. Modified-release preparation: Store at 5-25 ℃.

Lab interference

Oral Conventional preparation: Store at or below 30 ℃. Modified-release preparation: Store at 5-25 ℃.

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