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Cefdinir information from DrugsUpdate  

See Available Brands of Cefdinir in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December 1997.

Pharmacodynamics

Pharmacokinetics

Oral
Susceptible infections
Adult: 600 mg once daily as a single or in 2 divided doses.
Child: 14 mg/kg daily. Max: 600 mg daily.

Cefdinir Indications / Cefdinir Uses

Information Not Available

Cefdinir Adverse Reactions / Cefdinir Side Effects

Headache, dizziness, fever; nausea, vomiting, diarrhoea, abdominal pain; rash; leukopaenia, thrombocytopaenia, haemolytic anaemia.
Potentially Fatal: Anaphylaxis; renal and hepatic failure.

Precautions

Monitor
Response to therapy
Monitor patient's response to therapy. Notify health care provider if infection does not appear to improve or worsens.

Sensitivity
Review results of culture and sensitivity testing as appropriate. Ensure cefdinir is discontinued and another antimicrobial agent is started if sensitivity tests indicate that the organism is resistant to cefdinir.

Side effects
Monitor patient for GI, DERM, and general body side effects, and signs of superinfection. Inform health care provider if noted and significant. Immediately report severe diarrhea, diarrhea containing blood or pus, or severe abdominal cramping.

Hypersensitivity
Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients because of possible crossreactivity.

Renal Function
Use drug with caution in patients with renal impairment. Dosage adjustment is recommended in patients with Ccr less than 30 mL/min.

Superinfection
May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

Pseudomembranous colitis
Consider possibility in patients in whom diarrhea develops.


Hemodialysis patients
A single dose of 300 mg or 7 mg/kg (max, 300 mg) may be administered at the end of each dialysis session. Subsequent doses are then administered every other day.

Overdosage

Symptoms
Seizures, nausea, vomiting, epigastric distress, diarrhea.

Special Precautions

Penicillin-sensitive patients; superinfection; seizure; pseudomembranous colitis; pregnancy, lactation; renal or hepatic insufficiency.

Other Drug Interactions

Concomitant admin with antacids and Fe reduce the rate and extent of absorption. Probenecid reduces renal elimination. Antacids reduce rate and extent of absorption.

Other Interactions

Information Not Available

Dosage

Oral
Susceptible infections
Adult: 600 mg once daily as a single or in 2 divided doses.
Child: 14 mg/kg daily. Max: 600 mg daily.

Food(before/after)

May be taken with or without food

List of Contraindications

Cefdinir and Pregnancy

Caution when used during pregnancy.
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Cefdinir and Lactation

Caution when used during lactation

Cefdinir and Children

Safety and efficacy in children younger than 6 mo of age not established

Cefdinir and Geriatic

Information Not Available

Cefdinir and Other Contraindications

Hypersensitivity

Storage

Oral: Store at 25°C

Lab interference

Oral: Store at 25°C

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