logo image

Mebendazole information from DrugsUpdate  

See Available Brands of Mebendazole in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Mebendazole or MBZ, marketed as Ovex, Vermox, Antiox, Pripsen, is a benzimidazole drug that is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

Pharmacodynamics

Pharmacokinetics

Mebendazole acts by destroying the cytoplasmic microtubules in the worm's intestinal cells. This blocks the uptake of glucose and other nutrients resulting in death of the helminth.


Absorption


Poorly absorbed from the GI tract.


Distribution


Highly protein-bound.


Metabolism


Extensively hepatic; undergoes 1st-pass elimination.


Excretion


Mainly via faeces (as unchanged drug and metabolites); via urine (2%, as unchanged drug and metabolites).

Mebendazole Indications / Mebendazole Uses

Information Not Available

Mebendazole Adverse Reactions / Mebendazole Side Effects

Transient diarrhoea, abdominal pain, nausea, vomiting, headache, tinnitus, numbness, fever and dizziness. Potentially Fatal: Myelosuppression (high doses).

Precautions

Periodic assessment of organ system functions, including hematopoietic and hepatic, is advisable during prolonged therapy.

Special Precautions

Monitor blood counts and hepatic function especially in patients receiving high doses. Pregnancy and lactation.

Other Drug Interactions

Reduced plasma levels with enzyme inducers e.g. phenytoin, carbamazepine. Increased plasma levels with cimetidine.

Other Interactions

Food Interactions


Fatty food increases absorption

Dosage

Oral


Ascariasis Adult: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk. Child: >1 yr: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk. Hepatic impairment: Dose reduction may be required.


Oral


Trichuriasis Adult: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk. Child: >1 yr: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk. Hepatic impairment: Dose reduction may be required. Oral Hookworm infections Adult: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk. Child: >1 yr: 100 mg bid for 3 consecutive days. Alternatively, 500 mg as a single dose. A 2nd course may be given if patient is not cured within 3-4 wk. Hepatic impairment: Dose reduction may be required.


Oral


Enterobiasis Adult: 100 mg as a single dose; may repeat if necessary 2-3 wk after initial treatment. Child: >2 yr: 100 mg as a single dose; may repeat if necessary 2-3 wk after initial treatment. Hepatic impairment: Dose reduction may be required. Oral Capillariasis Adult: 200 mg bid for 20 days. Child: >2 yr: 200 mg bid for 20 days. Hepatic impairment: Dose reduction may be required. Oral Filariasis Adult: Caused by Mansonella perstans: 100 mg bid for 30 days; caused by Onchocerca volvulus: 1 g bid for 28 days. Child: >2 yr: 100 mg bid for 30 days. Hepatic impairment: Dose reduction may be required.


Oral


Toxocariasis Adult: 100-200 mg bid for 5 days; may continue for up to 20 days. Child: >2 yr: 100-200 mg bid for 5-20 days. Hepatic impairment: Dose reduction may be required.


Oral


Trichinellosis Adult: Caused by Trichinella spiralis: 200-400 mg tid for 3 days followed by 400-500 mg tid for 10 days. Child: >2 yr: 200-400 mg tid for 3 days followed by 500 mg tid for 10 days. Hepatic impairment: Dose reduction may be required. Oral Trichostrongyliasis Adult: Caused by Trichostronglus: 100 mg bid for 3 consecutive days. Child: >2 yr: 100 mg bid for 3 consecutive days. Hepatic impairment: Dose reduction may be required.


Oral


Dracunculiasis Adult: Caused by Dracunculus medinensis: 400-800 mg daily for 6 days.

Food(before/after)

May be taken with or without food

List of Contraindications

Mebendazole and Pregnancy

Caution when used during pregnancy.


Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Mebendazole and Lactation

Caution when used during lactation

Mebendazole and Children

The drug has not been extensively studied in children under two years; therefore, in the treatment of children under two years the relative benefit/risk should be considered.

Mebendazole and Geriatic

Information Not Available

Mebendazole and Other Contraindications

Hypersensitivity. Infants and children <2 yr

Storage

Information Not Available

Lab interference

Information Not Available

© 2011-2020 DrugsUpdate.com from UPilot INC. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to Millions of Visitors instantly.