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Bromhexine information from DrugsUpdate  

See Available Brands of Bromhexine in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Bromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties.


Bromhexine is an oral mucolytic agent with a low level of associated toxicity. Bromhexine acts on the mucus at the formative stages in the glands, within the mucus-secreting cells. Bromhexine disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces a less viscous mucus, which is easier to expectorate.


Bromhexine hydrochloride is rapidly absorbed from the gastrointestinal tract and undergoes extensive first-pass metabolism in the liver. Its oral bioavailability is stated to be only about 20%. It is widely distributed to body tissues and is highly bound to plasma proteins. About 85 to 90% of a dose is excreted in the urine mainly as metabolites. It has a terminal elimination half-life of up to about 12 hours. Bromhexine crosses the blood brain barrier and small amounts cross the placenta.

Bromhexine Indications / Bromhexine Uses

As mucolytic

Bromhexine Adverse Reactions / Bromhexine Side Effects

GI side effects; headache, dizziness, sweating, skin rashes.
Inhalation: Cough or bronchospasm.


Since mucolytics may disrupt the gastric mucosal barrier, bromhexine should be used with caution in patients with a history of gastric ulceration.
Clearance of bromhexine or its metabolites may be reduced in patients with severe hepatic or renal impairment.

Special Precautions

History of peptic ulceration; asthama patients. Severe hepatic or renal impairment

Other Drug Interactions

Information Not Available


Information Not Available


Information Not Available

List of Contraindications

Bromhexine and Pregnancy

Category A: Bromhexine has been taken by a large number of pregnant women and women of child bearing age without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the foetus having been observed.

Bromhexine and Lactation

It is not known whether bromhexine is excreted in breast milk or whether it has a harmful effect on the breastfeeding infant. Therefore it is not recommended for breastfeeding mothers unless the potential benefits to the patient are weighed against the possible risk to the infant.

Bromhexine and Children

Information Not Available

Bromhexine and Geriatic

Information Not Available

Bromhexine and Other Contraindications

Bromhexine is contraindicated for use in patients with known hypersensitivity or idiosyncratic reaction to bromhexine hydrochloride (or any of the other ingredients in the product).


Information Not Available

Lab interference

Information Not Available

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