Betaxolol information from DrugsUpdate
P - Contraindicated in pregnancy
L - Cautioned in lactation
Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and glaucoma. Being selective for beta1 receptors, it typically has fewer systemic side effects than non-selective beta-blockers, for example, not causing bronchospasm (mediated by beta2 receptors) as timolol may. Betaxolol also shows greater affininty for beta1 receptors than metoprolol. In addition to its effect on the heart, betaxolol reduces the pressure within the eye (intraocular pressure). This effect is thought to be caused by reducing the production of the liquid (which is called the aqueous humor) within the eye. The precise mechanism of this effect is not known. The reduction in intraocular pressure reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma.
Pharmacodynamics
Pharmacokinetics
Information Not Available
Betaxolol Indications / Betaxolol Uses
Information Not Available
Betaxolol Adverse Reactions / Betaxolol Side Effects
Topical use in eye: Mild ocular stinging & discomfort, usually transient & well – tolerated. Rarely, decreased corneal sensitivity erthyema, itching, keratitia & photophobia reported; tiredness, fatigue, headache, impotance, sleep disturbances, cold hands & feet, GI upsets, Bradycardia esp in elderly.
Precautions
Information Not Available
Special Precautions
Poor cardiac reserve, bronchospastic diseases, Dm, renal or hepatic impairment. May mask sings of hyperthyroidism. Gradual withdrawal is recommended.
Other Drug Interactions
May cause mydriasis when use concurrently wth epinephrine. Close observation needed when on β- blocker & catecholomine- depleting drugs such as resperpine, due to possible additive effects resulting in hypotension and or bradycardia. Caution when used concomitantly with adrenergic, psychotropic drugs. Enhances Cn channels blockers, anaesthetics & clonidine.
Other Interactions
Information Not Available
Dosage
Ophthalmic
Open – angle glaucoma & ocular hypertension: Adult; instil one drop of 0.25% or 0.5% solution bid.
Oral
Angina Pectoris
Hypertension; Adult: Initially, 10-20 mg once daily. May increase dose to 40mg/ day if necessary after 7- 14 days depending on the patient's response.
Elderly: Initial Dose of 5-10mg/day.
Food(before/after)
Information Not Available
List of Contraindications
Betaxolol and Pregnancy
Contraindicated in pregnancy
Betaxolol and Lactation
Cautioned in lactation
Betaxolol and Children
Information Not Available
Betaxolol and Geriatic
Information Not Available
Betaxolol and Other Contraindications
Sinus bradycardia, cardiogenic shock, overt cardiac failure. Pregnancy.
Storage
Information Not Available
Lab interference
Information Not Available
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