Aluminium Hydroxide information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *
Aluminium hydroxide, Al(OH)3, ATH, sometimes erroneously called Hydrate of alumina, is found in nature as the mineral gibbsite (also known as hydrargillite) and its three, much more rare forms, polymorphs: bayerite, doyleite and nordstrandite. Closely related are aluminium oxide hydroxide, AlO(OH), and aluminium oxide, Al2O3, differing only by loss of water. These compounds together are the major components of the aluminium ore bauxite.
Aluminum hydroxide is used for the relief of heartburn, sour stomach, and peptic ulcer pain and to promote the healing of peptic ulcers.
Pharmacodynamics
Pharmacokinetics
Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.
Absorption
Alumunium hydroxide reacts with hydrochloric acid in the stomach to form soluble aluminium chloride, which is absorbed from the GI tract.
Excretion
Absorbed aluminium is excreted via the urine. Insoluble aluminium salts formed in the intestines, eg, hydroxides, carbonates, phosphates and fatty acid derivatives, are excreted in the faeces.
Aluminium Hydroxide Indications / Aluminium Hydroxide Uses
Information Not Available
Aluminium Hydroxide Adverse Reactions / Aluminium Hydroxide Side Effects
Constipation; intestinal obstruction (with large doses); phosphate depletion may occur with prolonged admin or large doses.
Precautions
Information Not Available
Special Precautions
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hours before/after another medication to minimise drug interactions. Pregnancy and lactation.
Other Drug Interactions
Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Other Interactions
Food decreases gastric emptying time.
Dosage
Oral
Antacid
Adult: Up to 1 g daily.
Oral
Hyperphosphataemia in patients with chronic renal failure
Adult: Dose is adjusted to the individual patient's requirement. Up to 10 g/day may be given in divided doses with meals.
Max Dosage: 10 g daily in divided doses.
Food(before/after)
May be taken with or without food
List of Contraindications
Aluminium Hydroxide and Pregnancy
Caution when used during pregnancy
Aluminium Hydroxide and Lactation
Caution when used during lactation
Aluminium Hydroxide and Children
Information Not Available
Aluminium Hydroxide and Geriatic
Information Not Available
Aluminium Hydroxide and Other Contraindications
Hypersensitivity to aluminium salts
Storage
Information Not Available
Lab interference
Information Not Available
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