Betamethasone Dipropionate + Salicylic Acid information from DrugsUpdate  

Pharmacodynamics

Pharmacokinetics

Betamethasone dipropionate is a synthetic fluorinated corticosteroid. It is active topically and produces a rapid and sustained response in inflammatory dermatoses. It is also effective in less responsive conditions e.g. scalp psoriasis, chronic plaque psoriasis of the hands and feet. Salicylic acid has keratolytic action. It softens keratin, loosens cornified epithelium and desquamates the epidermis. It aids in the penetration of betamethasone.

Absorption
Betamethasone dipropionate: Percutaneous absorption depends on several factors e.g. use of occlusive dressings and integrity of the epidermal barrier. Salicylic acid: Exerts only local action after topical application.

Distribution
Betamethasone dipropionate: Once absorbed systemically, it is bound to plasma proteins in varying extents.

Metabolism
Betamethasone dipropionate: Once absorbed through the skin, it is metabolised mainly by the liver.

Excretion
Betamethasone dipropionate: Once absorbed through the skin, it is excreted largely renally; may also be excreted via the bile.

Betamethasone Dipropionate + Salicylic Acid Indications / Betamethasone Dipropionate + Salicylic Acid Uses

Information Not Available

Betamethasone Dipropionate + Salicylic Acid Adverse Reactions / Betamethasone Dipropionate + Salicylic Acid Side Effects

Pruritus, irritation, folliculitis, maceration of skin, skin atrophy, hypertrichosis, acneiform eruptions, secondary infection, hypopigmentation, perioral dermatitis, allergic contact dermatitis, striae and miliaria.

Precautions

Overdosage
Excessive prolonged use of topical corticosteroids can lead to pituitary-adrenal suppression resulting in secondary adrenal insufficiency. Excessive topical application of preparations containing salicylic acid may also result in symptoms of salicyclism. Treatment is symptomatic.

Special Precautions

Not to be used in or near the eyes. Avoid contact with mucous membranes. Prolonged topical corticosteroid treatment may result in systemic corticosteroid effects; may also lead to formation of striae or atrophy of the skin or subcutaneous tissue. Absorption of corticosteroid through the skin is increased when used with occlusive dressings. Caution when used in patients with stasis dermatitis or other skin diseases with impaired blood circulation. Treatment should be re-evaluated on a 4-wkly basis. Pregnancy and lactation.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Topical/Cutaneous
Psoriasis, Seborrhoeic dermatitis
Adult: As lotion (containing betamethasone 0.05% w/w as dipropionate and salicylic acid 2% w/w) or ointment (containing betamethasone 0.05% w/w as dipropionate and salicylic acid 3% w/w): Apply to the affected area 1-2 times daily.

Food(before/after)

Information Not Available

Betamethasone Dipropionate + Salicylic Acid and Pregnancy

Caution when used during pregnancy

Betamethasone Dipropionate + Salicylic Acid and Lactation

Caution when used during lactation

Betamethasone Dipropionate + Salicylic Acid and Children

Information Not Available

Betamethasone Dipropionate + Salicylic Acid and Geriatic

Information Not Available

Betamethasone Dipropionate + Salicylic Acid and Other Contraindications

Viral skin infections e.g. vaccinia, varicella and herpes simplex. Tuberculosis, acne rosacea, fungal skin infections (moniliasis), perioral dermatitis and ulcerative conditions.

Storage

Topical/Cutaneous
Lotion: Store <25°C. Ointment: Store <30°C

Lab interference

Topical/Cutaneous
Lotion: Store <25°C. Ointment: Store <30°C