Omeprazole + Domperidone information from DrugsUpdate  

Pharmacodynamics

Pharmacokinetics

Domperidone is a peripheral dopamine D2-receptor antagonist, which regulates the motility of gastric and small intestinal smooth muscle. It increases the duration of antral and duodenal contractions and also LES resting pressure, thus stimulating gastric emptying and is also effective in relief of symptoms of reflux esophagitis. Antiemetic activity is due to the blockade of dopamine receptors in the chemoreceptor trigger zone. Omeprazole inhibits the secretion of gastric acid by irreversibly blocking the enzyme system of H+/K+ ATPase of the gastric parietal cell. It is activated at an acidic pH to a sulphenamide derivative that binds irreversibly to H+/K+ ATPase, an enzyme system found at the secretory surface of parietal cells. It thereby inhibits the final transport of hydrogen ions (via exchange with K ions) into the gastric lumen.

Omeprazole + Domperidone Indications / Omeprazole + Domperidone Uses

Information Not Available

Omeprazole + Domperidone Adverse Reactions / Omeprazole + Domperidone Side Effects

Domperidone: Dry mouth, transient skin rash, itching, headache, diarrhoea and rarely nervousness. Omeprazole: Anaemia, eosinopaenia, urinary tract infection, skin rash, urticaria and pruritus, diarrhoea, headache, constipation, nausea, vomiting, flatulence and abdominal pain, dizziness and lightheadedness, somnolence, insomnia and vertigo, reversible confusion, agitation, depression and hallucinations, arthritic and myalgic symptoms.

Precautions

Information Not Available

Special Precautions

Domperidone can cause a rise in serum prolactin level resulting in galactorrhoea in females and less frequently gynaecomastia in males. Hypertensive crisis may occur in patients with phaeochromocytoma. Renal impairment or those at risk of fluid retention. Hepatic impairment; elderly. Exclude the possibility of malignancy if gastric ulcer is suspected, before initiating treatment with omeprazole, it may mask symptoms and delay diagnosis. Monitor patients on warfarin or phenytoin therapy, reduce dose if necessary.

Other Drug Interactions

Anticholinergics may antagonize beneficial effects of domperidone in reflux oesophagitis and dyspepsia. Decreased bioavailability of domperidone after prior admin of cimetidine or Na bicarbonate. Delayed elimination of diazepam, phenytoin and warfarin with omeprazole.

Other Interactions

Information Not Available

Dosage

Oral
Gastro-oesophageal reflux disease, Dyspepsia
Adult: 1 cap bid or as directed by the physician.

Food(before/after)

Information Not Available

Omeprazole + Domperidone and Pregnancy

Contraindicated in pregnancy

Omeprazole + Domperidone and Lactation

Information Not Available

Omeprazole + Domperidone and Children

Information Not Available

Omeprazole + Domperidone and Geriatic

Information Not Available

Omeprazole + Domperidone and Other Contraindications

Pregnancy. Domperidone is contraindicated in conditions associated with rise in prolactin level. Omeprazole is contraindicated in hypersensitive patients.

Storage

Information Not Available

Lab interference

Information Not Available