Cefoperazone + Sulbactam information from DrugsUpdate
Sulbactam is able to inhibit the most common forms of beta-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene.
In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.
Pharmacodynamics
Pharmacokinetics
Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). Sulbactam is a β-lactamase inhibitor and acts primarily by irreversible inactivation of β-lactamases.
Cefoperazone + Sulbactam Indications / Cefoperazone + Sulbactam Uses
Information Not Available
Cefoperazone + Sulbactam Adverse Reactions / Cefoperazone + Sulbactam Side Effects
Rash, skin reactions, fever, eosinophilia, urticaria, and pruritus. Haematological - Slight decreases in Hb conc and haematocrit value. GI effects, diarrhoea or loose stools, nausea, and vomiting. Mild, transient elevations of serum SGOT, SGPT, and alkaline phosphatase concentrations. Renal effects - Transient elevations in BUN and serum creatinine concentrations.
Precautions
Information Not Available
Special Precautions
Pregnancy, lactation
Other Drug Interactions
With aminoglycosides: Concomitant admin may increase risk of nephrotoxicity.
With heparin/warfarin: Concurrent use may cause marked hypoprothrombinemia and/or prolonged bleeding time.
Other Interactions
Information Not Available
Dosage
Intravenous
Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections
Adult: Ratio of sulbactam:cefoperazone is 1:1. Doses are expressed in terms of cefoperazone.
Mild to moderate infections: 1-2 g daily, given in equally divided doses every 12 hours.
Severe infections: Up to 4 g daily, given in equally divided doses every 12 hours; max dose of sulbactam: 4 g daily.
Child: Ratio of sulbactam:cefoperaone is 1:1. Doses are expressed in terms of cefoperazone.
Recommended doses: 20-40 mg/kg/day, given in equally divided doses every 6-12 hours.
For serious infections: Up to 160 mg/kg/day, given in 2-4 equally divided doses may be used.
Max dose of sulbactam: 80 mg/kg/day
Renal impairment: Dose adjustments may be needed.
Reconstitution
For IV infusion, each vial should be reconstituted with suitable amount of sterile water for injection, normal saline, 5% dextrose in water, and then diluted to 20 ml using the same diluent followed by admin over 15-60 minutes. For IV injection, each vial should be reconstituted as above and given over at least 3 minutes.
Food(before/after)
Information Not Available
List of Contraindications
Cefoperazone + Sulbactam and Pregnancy
Information Not Available
Cefoperazone + Sulbactam and Lactation
Information Not Available
Cefoperazone + Sulbactam and Children
Information Not Available
Cefoperazone + Sulbactam and Geriatic
Information Not Available
Cefoperazone + Sulbactam and Other Contraindications
Hypersensitivity. Known allergy to penicillins
Storage
Intravenous
Before reconstitution: Store below 25°C.
Reconstituted solutions are stable for 7 days at 2-8°C and for 24 hours at 8-25°C. All unused portions after the above stated time periods should be discarded.
Lab interference
Intravenous
Before reconstitution: Store below 25°C.
Reconstituted solutions are stable for 7 days at 2-8°C and for 24 hours at 8-25°C. All unused portions after the above stated time periods should be discarded.
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