Pantoprazole + Domperidone information from DrugsUpdate
P - Contraindicated in pregnancy
L - Caution when used during lactation
The combination of domperidone and pantoprazole is marketed as Dompan by Medley Pharmaceuticals.
Pharmacodynamics
Pharmacokinetics
Pantoprazole acts by selectively inhibiting the H+/K+-ATPase enzyme in the secretory canaliculus of the stimulated parietal cell. Domperidone stimulates GI activity by acting as a competitive antagonist at dopamine D2-receptors.
Pantoprazole + Domperidone Indications / Pantoprazole + Domperidone Uses
Information Not Available
Pantoprazole + Domperidone Adverse Reactions / Pantoprazole + Domperidone Side Effects
Pantoprazole: Diarrhoea, dizziness, pruritus, skin rashes, GIT infections; anaphylaxis, angioedema, chest pain, dyspnoea, erythema multiforme, gastroenteritis, hyperglycaemia, infection, Inj site reaction, jaundice, optic neuropathy, anterior ischaemia, pancreatitis, speech disorder. Domperidone: Headache, insomnia, nervousness, dizziness, thirst, lethargy, irritability, GI disturbances, hot flushes, mastalgia, galactorrhoea, gynaecomastia, menstrual irregularities, rash, pruritus, urticaria, stomatitis, conjunctivitis, urinary frequency, dysuria, oedema, palpitations, leg cramps, asthaenia, drug intolerance.
Precautions
Information Not Available
Special Precautions
Lactation. Pantoprazole: Not recommended in child <12 years. Long-term therapy may lead to bacterial overgrowth in the GIT. Domperidone: Increases serum prolactin levels resulting to galactorrhoea in females and gynaecomastia in males. Hypertensive crisis in patients with phaeochromocytoma.
Other Drug Interactions
Care should be exercised when domperidone is administered in combination with MAO inhibitors.
Other Interactions
Information Not Available
Dosage
Oral
Gastro-oesophageal reflux disease, Dyspepsia
Adult: Per tablet/capsule contains pantoprazole 40 mg and domperidone 10 mg: 1 tablet/capsule once daily.
Food(before/after)
Information Not Available
List of Contraindications
Pantoprazole + Domperidone and Pregnancy
Contraindicated in pregnancy
Pantoprazole + Domperidone and Lactation
Caution when used during lactation
Pantoprazole + Domperidone and Children
Information Not Available
Pantoprazole + Domperidone and Geriatic
Information Not Available
Pantoprazole + Domperidone and Other Contraindications
Pantoprazole: Hepatic impairment; hypersensitivity. Domperidone: History of hypersensitivity to dimenhydrinate or related compounds; GI haemorrhage, obstruction and perforation, or after surgery, pregnancy
Storage
Information Not Available
Lab interference
Information Not Available
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