Imidapril information from DrugsUpdate  

Pharmacodynamics

Pharmacokinetics

Imidapril prevents the conversion of angiotensin I to angiotension II by inhibiting ACE. It may also inhibit the degradation of bradykinin. It reduces preload and afterload in heart failure, and reduces left ventricular remodelling in MI.

Absorption Absorption of Imidapril is about 70%; peak plasma levels of Imidaprilat reached in about 7 hr. Distribution Protein-binding: 85% (Imidapril); 53% (Imidaprilat).

Metabolism Imidapril is hydrolysed to Imidaprilat in the liver.

Excretion 40% of an oral dose is excreted renally, the remaining dose in the faeces. Terminal half-life: >24 hr (Imidaprilat).

Imidapril Indications / Imidapril Uses

Information Not Available

Imidapril Adverse Reactions / Imidapril Side Effects

Dizziness, headache, fatigue, GI and taste disturbances, persistent dry cough and other upper respiratory tract symptoms, skin rash, angioedema, photosensitivity, renal impairment, hyperkalaemia, hyponatraemia, blood disorders, proteinuria, chest pain, palpitations, tachycardia, stomatitis, pancreatitis, cholestatic jaundice, alopecia, muscle cramps, paraesthesias, mood and sleep disturbances, impotence. Potentially Fatal: Excessive hypotension, which could result in MI or stroke in patients with ischaemic heart disease or cerebrovascular disease.

Precautions

Information Not Available

Special Precautions

Peripheral vascular diseases, generalised atherosclerosis, idiopathic or hereditary angioedema, heart failure, patients likely to be salt or water depleted. Assess renal function before and during therapy; monitor for proteinuria. Conduct regular WBC counts in SLE and scleroderma patients. Liver cirrhosis. Discontinue diuretics 2-3 days before starting therapy and resume later if required. Elderly.

Other Drug Interactions

Additive hyperkalaemic effects with potassium-sparing diuretics, potassium supplements, and other hyperkalaemic drugs. Reduced antihypertensive effects or additive adverse renal effects with NSAIDs. Potentially Fatal: Marked hypotension with diuretics, other antihypertensives, alcohol, other agents that lower BP.

Other Interactions

Information Not Available

Dosage

Oral Hypertension Adult: Initially, 5 mg once daily. 1st dose preferably given at bedtime. Maintenance: 10 mg daily. Max: 20 mg/day. Elderly: Initially, 2.5 mg daily. Max Dose: 10 mg daily. Renal impairment: Initially, 2.5 mg daily. Hepatic impairment: Initially, 2.5 mg daily. Special Populations Recommended dose in patients on diuretics: 2.5 mg daily.

Food(before/after)

Should be taken on an empty stomach. (Take 15 mins before meals. However, when initiating therapy, 1st dose should be given at bedtime.)

Imidapril and Pregnancy

Contraindicated in pregnancy

Imidapril and Lactation

Contraindicated in lactation

Imidapril and Children

Information Not Available

Imidapril and Geriatic

Information Not Available

Imidapril and Other Contraindications

Aortic stenosis or outflow tract obstruction; renovascular disease; ascites. Pregnancy and lactation.

Storage

Oral Store below 25 ℃

Lab interference

Oral Store below 25 ℃