Diacerein information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
Diacerein, also known as diacetylrhein, is a drug used in the treatment of osteoarthritis. It works by inhibiting interleukin-1.
Pharmacodynamics
Pharmacokinetics
Diacerein is an anthraquinone derivative that has been used in osteoarthritis. It is thought to act via inhibition of interleukin-1β.
Diacerein Indications / Diacerein Uses
Information Not Available
Diacerein Adverse Reactions / Diacerein Side Effects
Diarrhoea, epigastric pain, nausea, vomiting, intense yellow colouring of urine.
Precautions
Information Not Available
Special Precautions
Renal impairment. Monitor CBC, LFT and urinalysis every 6 months.
Other Drug Interactions
Decreased absorption with aluminium and/or magnesium hydroxide antacids. Increased risk of diarrhoea with laxatives, antibiotics. Avoid co-admin with fibres and phytates.
Other Interactions
Information Not Available
Dosage
Oral
Osteoarthritis
Adult: 50 mg bid.
CrCl (ml/min) Dosage Recommendation
<30 25 mg daily.
Food(before/after)
Should be taken with food. (Take with or immediately after meals.)
List of Contraindications
Diacerein and Pregnancy
Contraindicated in pregnancy
Diacerein and Lactation
Contraindicated in lactation
Diacerein and Children
Information Not Available
Diacerein and Geriatic
Information Not Available
Diacerein and Other Contraindications
Pregnancy, lactation. Hypersensitivity to anthraquinone derivatives.
Storage
Oral
Store at 15-25°C.
Lab interference
Oral
Store at 15-25°C.
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