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Paracetamol + Ibuprofen information from DrugsUpdate  

See Available Brands of Paracetamol + Ibuprofen in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food*

Information Not Available

Pharmacodynamics

Pharmacokinetics

Ibuprofen is a potent anti-inflammatory with analgesic and antipyretic action. Its analgesic and antipyretic effects are further reinforced by paracetamol.

Paracetamol + Ibuprofen Indications / Paracetamol + Ibuprofen Uses

Information Not Available

Paracetamol + Ibuprofen Adverse Reactions / Paracetamol + Ibuprofen Side Effects

Dyspepsia, heart burn, GI bleeding, rash, asthmatic attacks, thrombocytopenia, drug induced ulcer, drowsiness, hepatic necrosis, renal papillary necrosis, vision disturbances & disorientation; rarely nausea & vomiting can occur.

Potentially Fatal: Hematemesis, agranulocytosis, severe allergic reaction.

Precautions

Information Not Available

Special Precautions

Bronchial asthma, renal or hepatic disorders, bleeding disorders, CV diseases, hypertension, patients on anticoagulants, aspirin/NSAIDs induced allergy, pregnancy & lactation.

Other Drug Interactions

Ibuprofen antagonises the effects of furosemide & thiazides. Pethidine & propanthelene reduce absorption of paracetamol. Aspirin displaces ibuprofen from binding sites. NSAIDs blunt the effects of antihypertensives.

Potentially Fatal: Increased risk of GI ulceration & bleeding with anticoagulants. Paracetamol increases the risk of liver damage in chronic alcoholics. Ibuprofen increases the risk of methotrexate toxicity & lithium toxicity.

Other Interactions

Food Interaction
Food interferes with the rate of ibuprofen absorption

Dosage

Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: (Ibuprofen 400 mg + Paracetamol 325/500 mg) 1 tab 3-4 times daily.
Child: (Ibuprofen 100mg + Paracetamol 125mg) 1 dose tid or as required.

Food(before/after)

Information Not Available

List of Contraindications

Paracetamol + Ibuprofen and Pregnancy

Caution when used during pregnancy

Paracetamol + Ibuprofen and Lactation

Caution when used during lactation

Paracetamol + Ibuprofen and Children

Information Not Available

Paracetamol + Ibuprofen and Geriatic

Information Not Available

Paracetamol + Ibuprofen and Other Contraindications

Active peptic ulcer, history of hypersensitivity to either component, recent GI bleeding, neonates.

Storage

Information Not Available

Lab interference

Information Not Available

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