Paracetamol + Ibuprofen information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food*
Information Not Available
Pharmacodynamics
Pharmacokinetics
Ibuprofen is a potent anti-inflammatory with analgesic and antipyretic action. Its analgesic and antipyretic effects are further reinforced by paracetamol.
Paracetamol + Ibuprofen Indications / Paracetamol + Ibuprofen Uses
Information Not Available
Paracetamol + Ibuprofen Adverse Reactions / Paracetamol + Ibuprofen Side Effects
Dyspepsia, heart burn, GI bleeding, rash, asthmatic attacks, thrombocytopenia, drug induced ulcer, drowsiness, hepatic necrosis, renal papillary necrosis, vision disturbances & disorientation; rarely nausea & vomiting can occur.
Potentially Fatal: Hematemesis, agranulocytosis, severe allergic reaction.
Precautions
Information Not Available
Special Precautions
Bronchial asthma, renal or hepatic disorders, bleeding disorders, CV diseases, hypertension, patients on anticoagulants, aspirin/NSAIDs induced allergy, pregnancy & lactation.
Other Drug Interactions
Ibuprofen antagonises the effects of furosemide & thiazides. Pethidine & propanthelene reduce absorption of paracetamol. Aspirin displaces ibuprofen from binding sites. NSAIDs blunt the effects of antihypertensives.
Potentially Fatal: Increased risk of GI ulceration & bleeding with anticoagulants. Paracetamol increases the risk of liver damage in chronic alcoholics. Ibuprofen increases the risk of methotrexate toxicity & lithium toxicity.
Other Interactions
Food Interaction
Food interferes with the rate of ibuprofen absorption
Dosage
Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: (Ibuprofen 400 mg + Paracetamol 325/500 mg) 1 tab 3-4 times daily.
Child: (Ibuprofen 100mg + Paracetamol 125mg) 1 dose tid or as required.
Food(before/after)
Information Not Available
List of Contraindications
Paracetamol + Ibuprofen and Pregnancy
Caution when used during pregnancy
Paracetamol + Ibuprofen and Lactation
Caution when used during lactation
Paracetamol + Ibuprofen and Children
Information Not Available
Paracetamol + Ibuprofen and Geriatic
Information Not Available
Paracetamol + Ibuprofen and Other Contraindications
Active peptic ulcer, history of hypersensitivity to either component, recent GI bleeding, neonates.
Storage
Information Not Available
Lab interference
Information Not Available
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