Glimepiride + Metformin information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
Information Not Available
Pharmacodynamics
Pharmacokinetics
Glimepiride stimulates the insulin release from functioning pancreatic β-cells and inhibits gluconeogenesis at hepatic cells. It also increases insulin sensitivity at peripheral target sites. Metformin decreases hepatic gluconeogenesis, decreases intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilisation).
Glimepiride + Metformin Indications / Glimepiride + Metformin Uses
Information Not Available
Glimepiride + Metformin Adverse Reactions / Glimepiride + Metformin Side Effects
Diarrhoea, vomiting, metallic taste, rash, isolated transaminase elevations, cholestatic jaundice, allergic skin reactions, photosensitivity reactions, leukopaenia, agranulocytosis, thrombocytopaenia, haemolytic anaemia, aplastic anaemia, pancytopaenia, blurred vision.
Potentially Fatal: Lactic acidosis.
Precautions
Information Not Available
Special Precautions
Renal and hepatic impairment. Avoid alcohol consumption. Hypoglycaemic episodes.
Other Drug Interactions
Concomitant admin with propranolol increases Cmax, AUC, and T1/2 of glimepiride. Aspirin increases the mean AUC of glimepiride. Furosemide increases the Cmax of metformin.
Potentially Fatal: NSAIDS, salicylates, sulfonamides, chloramphenicol, coumarins, probenecid, MAOs, and beta blockers potentiate the hypoglycemic action of glimepiride.
Other Interactions
Information Not Available
Dosage
Oral
Type 2 diabetes mellitus
Adult: Per tablet contains glimepiride 1 mg and metformin 250 mg or glimepiride 2 mg and metformin 500 mg: Take as directed. Titrate according to response.
Food(before/after)
Information Not Available
List of Contraindications
Glimepiride + Metformin and Pregnancy
Contraindicated in pregnancy
Glimepiride + Metformin and Lactation
Contraindicated in lactation
Glimepiride + Metformin and Children
Information Not Available
Glimepiride + Metformin and Geriatic
Information Not Available
Glimepiride + Metformin and Other Contraindications
Hypersensitivity diabetic ketoacidosis (DKA); renal dysfunction; CHF (CHF), patients undergoing radiological studies; acute or chronic metabolic acidosis. Pregnancy, lactation.
Storage
Information Not Available
Lab interference
Information Not Available
FOLLOW US:
