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Sulfamoxole + Trimethoprim information from DrugsUpdate  

See Available Brands of Sulfamoxole + Trimethoprim in India

P - Caution when used during pregnancy
L - Contraindicated in lactation
LI - Lab*

Information Not Available

Pharmacodynamics

Pharmacokinetics

Sulfamoxole interferes with nucleic acid synthesis in microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. Trimethoprim inhibits the conversion of bacterial dihydrofolic acid to tetrahydrofolic acid which is important for the synthesis of DNA.

Sulfamoxole + Trimethoprim Indications / Sulfamoxole + Trimethoprim Uses

Information Not Available

Sulfamoxole + Trimethoprim Adverse Reactions / Sulfamoxole + Trimethoprim Side Effects

Nausea, vomiting, anorexia, diarrhoea, glossitis, stomatitis, drowsiness, headache, depression, hallucinations, hypersensitivity skin reaction, photosensitivity, drug fever, crystalluria, elevation of liver enzymes, hypothyroidism, hyponatremia, hyperkalemia, kernicterus in premature neonates, aseptic meningitis, cholestatic jaundice.

Potentially Fatal: Anaphylaxis; Stevens-Johnson syndrome; blood dyscrasias e.g. agranulocytosis, aplastic anaemia; toxic epidermal necrolysis.

Precautions

Overdosage
Nausea, vomiting, allergic reactions. If within 3 hours of ingestion, gastric lavage to be performed, followed by IM folinic acid, vitamin B12 and supportive treatment. Perform LFT once a week and FBC twice a wk for 3 weeks.

Special Precautions

Renal insufficiency, elderly, blood dyscrasias, G6PD deficiency, AIDS, patient with potential folate deficiency, children with fragile X chromosome associated with mental retardation. Perform regular haematological examination.

Other Drug Interactions

Concurrent use increases risk of blood dyscrasias with azathioprine, methotrexate, pyrimethamine; increased risk of hyperkalaemia with ACE inhibitors; increased risk of hyponatraemia when used with both potassium-sparing diuretics and thiazides; increases risk of bleeding with warfarin; increases risk of lithium toxicity; increases digoxin, phenytoin, procainamide, lamivudine, stavudine, repaglinide, rosiglitazone, dofetilide serum levels; decreases ciclosporin levels. Concurrent use with dapsone increases serum levels of both and increases risk of dapsone toxicity. Concurrent may potentiate antidiabetic effect of sulphonylureas.

Potentially Fatal: Concurrent use increases risk of blood dyscrasias with clozapine and pyrimethamine.

Other Interactions

Information Not Available

Dosage

Oral
Susceptible infections, Urinary tract infections, Genital infections, Gastrointestinal infections, Ear, nose and/or throat infections, Respiratory tract infections, Skin infections
Adult: Each tablet contains sulfamoxole 400 mg and trimethoprim 60 mg: Initially, 2 tablets, followed by 1 tablet bid. Each 5 ml contains sulfamoxole 200 mg and trimethoprim 40 mg: Initially, 20 ml, followed by 10 ml bid.
Child: Each 5 ml contains sulfamoxole 200 mg and trimethoprim 40 mg: 4-12 months: Initially, 2.5-5 ml followed by 1.2-2.5 ml bid; 1-6 years: Initially, 5-10 ml, followed by 2.5-5 ml bid, 6-12 years: Initially, 10-15 ml, followed by 5-10 ml bid.
Renal impairment: Dose reduction is advisable.

Food(before/after)

Information Not Available

List of Contraindications

Sulfamoxole + Trimethoprim and Pregnancy

Caution when used during pregnancy

Sulfamoxole + Trimethoprim and Lactation

Contraindicated in lactation

Sulfamoxole + Trimethoprim and Children

Information Not Available

Sulfamoxole + Trimethoprim and Geriatic

Information Not Available

Sulfamoxole + Trimethoprim and Other Contraindications

Hypersensitivity to sulfonamides; severe renal or hepatic impairment; porphyria, SLE; serious haematological disorders; megaloblastic anemia secondary to folate depletion. Infants <2 months; pregnancy (3rd trimester), lactation.

Storage

Oral
Store below 25°C

Lab interference

Oral
Store below 25°C

Sulfamoxole + Trimethoprim brands in India:

Cortina Supristol

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