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Sulfadiazine + Trimethoprim information from DrugsUpdate  

See Available Brands of Sulfadiazine + Trimethoprim in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation
FI - Food*
LI - Lab*

Information Not Available

Pharmacodynamics

Pharmacokinetics

Sulphadiazine is a short-acting sulphonamide derivative with bacteriostatic action through competitive inhibition of bacterial synthesis of folic acid. Trimethoprim inhibits enzymes folic acid pathway, preventing the reaction of the dihydrolic acid to tetrahydrofolate.

Sulfadiazine + Trimethoprim Indications / Sulfadiazine + Trimethoprim Uses

Information Not Available

Sulfadiazine + Trimethoprim Adverse Reactions / Sulfadiazine + Trimethoprim Side Effects

Nausea, vomiting, anorexia and diarrhoea. Hypersensitivity, skin reactions; lumbar pain, haematuria, oliguria, anuria, crystallisation in urine, thrombocytopaenia, leucopaenia, eosinophilia, neonatal jaundice and kernicterus.

Potentially Fatal: Stevens-Johnson syndrome; agranulocytosis, thrombocytopaenia, jaundice in new born. Mild GI disturbances; pruritus; skin rash; sulfonamide-like skin reactions; disturbances of liver enzyme values, cholestatic jaundice; raised serum creatinine and BUN; fever; anaphylaxis; aseptic meningitis; hematologic disturbances; photosensitivity; induce hyperkalemia particularly in HIV patients being treated for Pneumocystis carinii pneumonia or in the elderly.

Precautions

Information Not Available

Special Precautions

Elderly, adequate fluid intake, G6PD deficiency, AIDS; actual or possible folate deficiency, child with fragile X chromosome associated with mental retardation; discontinue in case of skin rash; perform regular hematological examination.

Other Drug Interactions

Sulphadiazine: Potentiates antidiabetic effect of sulphonylureas. Action antagonised by para-aminobenzoinc acid and procaine group of local anaesthetics.
Trimethoprim: Potentiate effects of phenytoin, digoxin, procainamide, warfarin. Reduces renal excretion of zalcitabine, zidovudine and lamivudine. Dapsone; rifampicin; increase risk of nephrotoxicity when given with cyclosporin; severe hyperkalaemia when given with ACE inhibitor; depressants of bone marrow function; risk of megaloblastic anemia with other folate inhibitors eg pyrimethamine, methotrexate; hyponatraemia if receiving diuretics concurrently.

Potentially Fatal: Potentiates oral anticoagulants, methotrexate and phenytoin. Ascorbic acid and hexamine may precipitate crystalluria; metabolism of oral hypoglycaemics may be inhibited.

Other Interactions

Food Interaction
Avoid vit C or acidifying agents to prevent crystalluria.

Dosage

Oral
Urinary tract infections
Adult: Per tablet contains sulfadiazine 410 mg and trimethoprim 90 mg or per 5 mL suspension contains sulfadiazine 205 mg and trimethoprim 45 mg: 2 tablets or 20 mL as a single dose every 24 hours.
Child: >3 months: Per day: 14 mg sulfadiazine/kg+3 mg trimethoprim/kg. Daily dose is divided into 2 equal doses given every 12 hours.

Food(before/after)

Information Not Available

List of Contraindications

Sulfadiazine + Trimethoprim and Pregnancy

Contraindicated in pregnancy

Sulfadiazine + Trimethoprim and Lactation

Contraindicated in lactation

Sulfadiazine + Trimethoprim and Children

Information Not Available

Sulfadiazine + Trimethoprim and Geriatic

Information Not Available

Sulfadiazine + Trimethoprim and Other Contraindications

Hypersensitivity; severe renal/hepatic impairment; blood dyscrasias, porphyrias, serious hematological disorders; megaloblastic anemia secondary to folate depletion. Infants ≤2 months; pregnancy (at term), lactation.

Storage

Information Not Available

Lab interference

Information Not Available

Sulfadiazine + Trimethoprim brands in India:

Aubril

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