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S-Amlodipine + Nebivolol information from DrugsUpdate  

See Available Brands of S-Amlodipine + Nebivolol in India

P - Contraindicated in pregnancy
L - Contraindicated in lactation

Information Not Available

Pharmacodynamics

Pharmacokinetics

S-amlodipine is an enantiomer of amlodipine, which blocks Ca ion outside the cardiac muscle cells and vascular smooth muscle cells via the Ca channel of cytomembrane. It directly dilates vascular smooth muscle, resisting hypertension. The mechanism of remitting angina pectoris is not yet determined completely. It can decrease myocardial ischemia through dilatation of the peripheral small artery, decreasing peripheral resistance, causing the reduction of energy consumption, and O2 requirement of cardiac muscle and dilating the coronary artery and coronary small artery at normal and ischemic areas, increasing the O2 supply of the cardiac muscle of the coronary spasm patients.
Nebivolol exerts its actions by exhibiting a high selectivity for beta-1 adrenergic receptors and also by reducing the peripheral vascular resistance by modulating NO release.

S-Amlodipine + Nebivolol Indications / S-Amlodipine + Nebivolol Uses

Information Not Available

S-Amlodipine + Nebivolol Adverse Reactions / S-Amlodipine + Nebivolol Side Effects

Headache, fatigue, parasthesias and dizziness, insomnia, nausea, abdominal pain, flushing, pruritus, skin rash, dyspnea, weakness, muscular spasm, and dyspepsia.

Precautions

Information Not Available

Special Precautions

History of allergies, psoriasis, hyperthyroidism, peripheral arterial disease, diabetes, elderly.

Other Drug Interactions

Information Not Available

Other Interactions

Information Not Available

Dosage

Oral
Hypertension
Adult: 1 cap [S-Amlodipine 2.5mg + Nebivolol 5mg] once daily.

Food(before/after)

Information Not Available

List of Contraindications

S-Amlodipine + Nebivolol and Pregnancy

Contraindicated in pregnancy

S-Amlodipine + Nebivolol and Lactation

Contraindicated in lactation

S-Amlodipine + Nebivolol and Children

Information Not Available

S-Amlodipine + Nebivolol and Geriatic

Information Not Available

S-Amlodipine + Nebivolol and Other Contraindications

Allergic to dihydropyridine Ca antagonist, hypersensitivity to the active substance or to any of the excipients, liver insufficiency or liver function impairment. Pregnancy, lactation.

Storage

Information Not Available

Lab interference

Information Not Available

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