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Salbutamol + Theophylline information from DrugsUpdate  

See Available Brands of Salbutamol + Theophylline in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food*
LI - Lab*

Information Not Available

Pharmacodynamics

Pharmacokinetics

Salbutamol is a selective β2-agonist. It causes bronchial smooth muscle relaxation via the cyclic adenyl cyclase (cAMP) system. Theophylline is a phosphodiesterase inhibitor. It enhances intracellular cAMP conc thereby contributing to bronchial smooth muscle relaxation. It also suppresses airway hyper-response to stimuli. Advantage of this combination is the additive effect allowing reduction of individual doses.

Salbutamol + Theophylline Indications / Salbutamol + Theophylline Uses

Information Not Available

Salbutamol + Theophylline Adverse Reactions / Salbutamol + Theophylline Side Effects

Seizures, tremor, muscle cramps, palpitation, hypokalaemia, headache, anorexia, nausea, anxiety, irritability, insomnia, rarely rash and angioedema.

Potentially Fatal: Arrhythmias including premature ventricular contractions.

Precautions

Information Not Available

Special Precautions

Hepatic impairment, cardiac failure, hypertension, arrhythmias, pulmonary oedema, hyperthyroidism, diabetes mellitus, history of peptic ulcer and convulsive disorders, patients on MAOIs or tricyclic antidepressants, high fever, neonates and infants, pregnancy, lactation.

Other Drug Interactions

Increased theophylline toxicity with propranolol, cimetidine, erythromycin (7-5 days), quinolone antibiotics. Reduced efficacy with rifampicin, phenobarbitone, phenytoin, carbamazepine, sulfinpyrazone and smoking. Increased risk of hypokalaemia with diuretics.

Potentially Fatal: With anaesthetics, pancuronium bromide and sympathomimetics (increased risk of arrhythmias).

Other Interactions

Food Interaction
Absorption of theophylline reduced variably by different types of food.

Dosage

Oral
Emphysema, Chronic bronchitis, Asthma
Adult: Per tab contains salbutamol 2 mg and theophylline 100 mg: 1 or 2 tab 3-4 times daily.
Child: Child (under 6 years) salbutamol (0.5-1mg) + theophylline (25-50mg) t.i.d/q.i.d. SR (S 4mg+T 300mg) 1 tab b.i.d.

Food(before/after)

Information Not Available

List of Contraindications

Salbutamol + Theophylline and Pregnancy

Caution when used during pregnancy

Salbutamol + Theophylline and Lactation

Caution when used during lactation

Salbutamol + Theophylline and Children

Information Not Available

Salbutamol + Theophylline and Geriatic

Information Not Available

Salbutamol + Theophylline and Other Contraindications

Hypersensitivity, thyrotoxicosis

Storage

Information Not Available

Lab interference

Information Not Available

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