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Piperacillin + Tazobactam information from DrugsUpdate  

See Available Brands of Piperacillin + Tazobactam in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Piperacillin/Tazobactam is a combination antibiotic containing the extended-spectrum penicillin antibiotic piperacillin and the β-lactamase inhibitor tazobactam. It is commonly marketed by Neomed under the trade name TAZOMED and Wyeth under the trade name Tazocin or Zosyn.PENSAR under the trade name 'IVITAZ' & Revotaz by Alkem laboratories, "TAZOPEN" by Biochem pharmacutical ind. ltd. in India & Nigeria.

Pharmacodynamics

Pharmacokinetics

Piperacillin has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against gm+ve organisms eg E. faecalis and B. fragilis. Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. In combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria.

Distribution
Piperacillin and tazabactam: 30% bound to plasma proteins. Widely distributed into body tissues and fluids.

Metabolism
Piperacillin: metabolised to a desethyl metabolite. Tazobactam: metabolised to a single metabolite that lacks pharmacological and antibacterial activities.

Excretion

Half-life of piperacillin and tazobactam ranges from 0.7-1.2 hours. Eliminated via kidney by glomerular filtration and tubular secretion. Piperacillin: 68% excreted unchanged in urine.Tazobactam: 80% excreted unchanged in urine.

Piperacillin + Tazobactam Indications / Piperacillin + Tazobactam Uses

Information Not Available

Piperacillin + Tazobactam Adverse Reactions / Piperacillin + Tazobactam Side Effects

Diarrhoea, skin rashes, occasionally platelet mediated bleeding, rigors, malaise, ulcerative stomatitis. Inj-site reactions such as pain, erythema, induration and thrombophlebitis.


Potentially Fatal: Serious, anaphylactic reactions.

Precautions

Information Not Available

Special Precautions

Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment.

Other Drug Interactions

Probenecid prolongs half lives of piperacillin and tazobactam. Increased risk of methotrexate toxicity when used together.

Potentially Fatal: Interacts with heparin and other oral anticoagulants. Prolongs the neuromuscular blockade of vecuronium and non-depolarizing muscle relaxants.

Other Interactions

Information Not Available

Dosage

Adult: Initial dose: 4.5 g (piperacillin 4 g and tazobactam 0.5 g) every 6 hours for 7-14 days. When used empirically, combination with an aminoglycoside or antipseudomonal fluoroquinolone is recommended. May be given via infusion over 30 minutes. If Pseudomonas aeruginosa is not isolated, may discontinue aminoglycoside.
Child: 2-8 months: 80 mg of piperacillin/kg every 8 hours; ≥9 month and ≤40 kg: 100 mg of piperacillin/kg every 8 hours.
Renal impairment: For haemodialysis: admin an additional dose of 0.75 g after each dialysis session on hemodialysis days.
CrCl (ml/min)         Dosage Recommendation
>40                       4.5 g every 6 hours
20-40                    3.375 g every 6 hours
<20                       2.25 g every 6 hours
Haemodialysis       2.25 g every 8 hours
CAPD                     2.25 g every 8 hours

Intravenous
Severe infections
Adult: 3.375 g (piperacillin 3 g and tazobactam 0.375 g) every 6 hours for 7-10 days. May be given via infusion over 30 minutes.
Renal impairment: For haemodialysis, admin an additional dose of 0.75 g after each dialysis session on haemodialysis days.
CrCl (ml/min)         Dosage Recommendation
>40                       3.375 g every 6 hours
20-40                    2.25 g every 6 hours
<20                       2.25 g every 8 hours
Haemodialysis      2.25 g every 12 hours
CAPD                    2.25 g every 12 hours


Incompatibility
Not compatible with tobramycin for simultaneous admin via Y-site infusion.

Food(before/after)

Information Not Available

List of Contraindications

Piperacillin + Tazobactam and Pregnancy

Caution when used during pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Piperacillin + Tazobactam and Lactation

Caution when used during lactation

Piperacillin + Tazobactam and Children

Information Not Available

Piperacillin + Tazobactam and Geriatic

Information Not Available

Piperacillin + Tazobactam and Other Contraindications

Hypersensitivity

Storage

Intravenous
Injection vials should be stored at 20-25°C prior to reconstitution

Lab interference

Intravenous
Injection vials should be stored at 20-25°C prior to reconstitution

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