Tranexamic acid + Mefenamic acid information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
LI - Lab*
Information Not Available
Pharmacodynamics
Pharmacokinetics
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Tranexamic acid + Mefenamic acid Indications / Tranexamic acid + Mefenamic acid Uses
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Tranexamic acid + Mefenamic acid Adverse Reactions / Tranexamic acid + Mefenamic acid Side Effects
Diarrhoea, nausea, vomiting, vision, giddiness, hypotension, thromboembolism & thrombosis. Bronchospasm; headache, drowsiness, insomnia, visual disturbances; utricaria, rash, thrombocytopaenia, aplastic anaemia, agranulocytosis. Autoimmune; convulsions (0verdosage) with mefenamic acid.
Precautions
Information Not Available
Special Precautions
Mild to moderate renal impairment, long term treatment of hereditary angioedema. Ureteral obstruction, previous history of thromboembolic disease, concomitant adiwn with factorIX complex concentrates or anti- inhibitor coagulant concentrates, thoracic or abdominal surgery, disseminated intravascular coagulation (DIC), haematuria, active intravascular clotting, asthama. Monitor blood counts & liver function during long- term therapy. Drowsiness may affect ability to perform skilled tasks.
Other Drug Interactions
Mefenamic acid enhances acitivity of oral anticoagulants but rarely significant. Increases risk of GI irritation with alcohol. Tranexamic acid has increased risk of thrombus formation with oestrogens.
Other Interactions
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Dosage
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Food(before/after)
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List of Contraindications
Tranexamic acid + Mefenamic acid and Pregnancy
Contraindicated in pregnancy
Tranexamic acid + Mefenamic acid and Lactation
Contraindicated in lactation
Tranexamic acid + Mefenamic acid and Children
Information Not Available
Tranexamic acid + Mefenamic acid and Geriatic
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Tranexamic acid + Mefenamic acid and Other Contraindications
Severe renal failure, thromboemolic disease, massive upper urinary tract, haemorrage; pronounced thrombotic tendency or colour vision disorders, thrombophlebitis. Impaired liver function; subarachnoid bleeding. Inflammatory bowel disease; peptic ulcer; neonates; pregnancy (third trimester), lactation.
Storage
Information Not Available
Lab interference
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