Ciprofloxacin + Tinidazole information from DrugsUpdate
P - Caution when used during pregnancy
L - Contraindicated in lactation
FI - Food *
Information Not Available
Pharmacodynamics
Pharmacokinetics
Ciprofloxacin is bactericidal against enteropathogens like Shigella, Salmonella, E coli, C jejuni, Vibrio cholerae etc. It acts by inhibition of DNA synthesis. Tinidazole is a potent anaerobicide. It is also effective against Entameba & Giardia. It acts by damaging DNA strands. This combination has the advantage of being effective against both bacteria & protozoa. Entameba requires normal faecal flora for its survival; ciprofloxacin kills the pathogenic intestinal bacteria & alters intestinal flora, & tinidazole directly eradicates Entameba. This combination can also be used in other systemic infections caused by susceptible organisms.
Ciprofloxacin + Tinidazole Indications / Ciprofloxacin + Tinidazole Uses
Information Not Available
Ciprofloxacin + Tinidazole Adverse Reactions / Ciprofloxacin + Tinidazole Side Effects
Nausea, headache, vomiting, fatigue, abdominal pain, depression, dyspepsia, constipation, dry mouth, sometimes diarrhea, metallic taste, urticaria, erythema & rashes; rarely convulsions & hematological changes.
Potentially Fatal: Severe hypersensitivity reaction (rarely).
Precautions
Overdosage
Unabsorbed drug may be removed by gastric lavage or induced emesis. Haemodialysis or peritoneal dialysis may be useful in removing ciprofloxacin, especially if the renal function is impaired.
Special Precautions
Renal impairment, history of seizures; ensure adequate hydration & urinary output; avoid alcohol ingestion. Not recommended for use in lactation and pregnancy. Not recommended for children. Patients with CNS disorders. Inadequate water intake during treatment may cause crystalluria.
Other Drug Interactions
Antacids, sucralfate, calcium, Fe & Zn prep reduce absorption of ciprofloxacin. Concurrent use with ciclosporin may lead to transient increases in serum creatinine levels. Increases plasma levels and elimination half-life of theophylline; potentiates oral anticoagulant effects; disulfiram-like effect with alcohol. May affect metabolism of caffeine resulting in reduced clearance of caffeine.
Other Interactions
Food Interactions
Milk and food may reduce rate but not extent of absorption of ciprofloxacin.
Dosage
Oral
Appendicitis, Diarrhoea and dysentery of protozoal, bacterial and mixed origin, Postoperative anaerobic infections, Pulmonary infections, Lung abscess
Adult: As tablet containing ciprofloxacin (mg)/tinidazole (mg): 500/600, 250/300. Usually 1 tablet bid for 5-10 days depending on severity and response.
Food(before/after)
Information Not Available
List of Contraindications
Ciprofloxacin + Tinidazole and Pregnancy
Caution when used during pregnancy
Ciprofloxacin + Tinidazole and Lactation
Contraindicated in lactation
Ciprofloxacin + Tinidazole and Children
Information Not Available
Ciprofloxacin + Tinidazole and Geriatic
Information Not Available
Ciprofloxacin + Tinidazole and Other Contraindications
Hypersensitivity, patients with a history of blood dyscrasias.
Storage
Information Not Available
Lab interference
Information Not Available
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