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Ethambutol + Isoniazid information from DrugsUpdate  

See Available Brands of Ethambutol + Isoniazid in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *
LI - Lab *

Ethambutol is a bacteriostatic antimycobacterial drug prescribed to treat tuberculosis. It is usually given in combination with other tuberculosis drugs, such as isoniazid, rifampicin and pyrazinamide.

It is sold under the trade names Myambutol and Servambutol.

Pharmacodynamics

Pharmacokinetics

Information Not Available

Ethambutol + Isoniazid Indications / Ethambutol + Isoniazid Uses

Information Not Available

Ethambutol + Isoniazid Adverse Reactions / Ethambutol + Isoniazid Side Effects

Peripheral neuritis, optic neuritis; psychotic reactions, convulsions, nausea, vomiting, fatigue, epigastric distress, visual disturbances, fever, rash, pyridoxine deficiency. Retrobulbar neuritis with a reduction in visual acutiy, constriction of visual field, central or peripheral scotoma & green- red colour blindness. Retinal haemorrhage (rare); reduced renal clearance of urates (acute gout); GI disturbances e.g nausea, vomiting, abdominal pain, anorxia, rash, headache, dizziness, confusion, hallucinations, malaise, jaundice, thrombocytopaenia; pulmonary infiltrates. Hepatitis (rare); fatalities following liver necrosis; hepatotoxicity.

Precautions

Information Not Available

Special Precautions

Renal impairment; convulsive disorders; history of psychosis; patients at risk of neuropathy or pyridoxine deficiency e.g diabetic, alcoholic, malnourished, uraemic, infected with HIV. Check liver function before treatment. Impaired pre- treatment visual acuity, impaired renal function; elderly, pregnancy, lactation.

Other Drug Interactions

Antagonises hypoglycaemic action of insulin. Pyridoxine antagonises INH effects, absorption delayed or reduced by Al hydroxide. Synergistic effect with other antitubercular agents. Increased risk of hepatitis with alcohol, hepatotoxicity with rifampicin.

Other Interactions

Food Interaction

Dosage

Information Not Available

Food(before/after)

Information Not Available

List of Contraindications

Ethambutol + Isoniazid and Pregnancy

Caution when used during pregnancy.

Ethambutol + Isoniazid and Lactation

Caution when used during lactation

Ethambutol + Isoniazid and Children

Information Not Available

Ethambutol + Isoniazid and Geriatic

Information Not Available

Ethambutol + Isoniazid and Other Contraindications

Hypersensitivity, previous history of hepatic damage during INH therapy; optic neuritis, severe renal failure, history of epilepsy; child < 6 years.

Storage

Information Not Available

Lab interference

Information Not Available

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