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Clopamide information from DrugsUpdate  

See Available Brands of Clopamide in India

P - Caution when used during pregnancy
L - Caution when used during lactation

Clopamide is a piperidine diuretic.

Mechanism of Action of Clopamide
Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.

Pharmacodynamics

Pharmacokinetics

Clopamide reduces the reabsorption of electrolytes from the renal tubules, hence increasing the excretion of Na and chloride ions and consequently of water. It also reduces the glomerular filtration rate.


Onset
1-2 hours.

Duration
Up to 24 hours.

Clopamide Indications / Clopamide Uses

Information Not Available

Clopamide Adverse Reactions / Clopamide Side Effects

Electrolyte imbalance; hyperglycaemia; gout; dry mouth; thirst; weakness; muscle pain and cramp; seizures; hypotension; GI disturbances; anorexia; sialadenitis; headache; impotence; yellow vision; hypersensitivity reactions; cholestatic jaundice; pancreatitis; blood dyscrasias; glycosuria; dizziness; photosensitivity reactions, postural hypotension, paraesthesia .

Precautions

Information Not Available

Special Precautions

Fluid and electrolyte disturbances; hepatic cirrhosis; gout; diabetes mellitus. Elderly; severe heart failure; renal or hepatic impairment. Monitor blood glucose concentrations in patients taking antidiabetics. Pregnancy and lactation.

Other Drug Interactions

Digitalis glycosides; drugs that prolong QT interval; other antihypertensives; competitive muscle relaxants; pressor amines; corticosteroids, corticotrophin; β2-agonists, α-blockers; ACE inhibitors; NSAIDs; alcohol, barbiturates; opioids; lithium; allopurinol; tetracyclines; carbenoxolone; hypoglycaemics.

Other Interactions

Information Not Available

Dosage

Oral
Oedema
Adult: 10-40 mg daily or on alternate days, reduce frequency for maintenance.

Oral
Hypertension
Adult: 5-10 mg daily alone or in conjunction with other antihypertensives.

Food(before/after)

Information Not Available

List of Contraindications

Clopamide and Pregnancy

Caution when used during pregnancy

Clopamide and Lactation

Caution when used during lactation

Clopamide and Children

Information Not Available

Clopamide and Geriatic

Information Not Available

Clopamide and Other Contraindications

Severe hepatic or renal impairment; anuria; Addison's disease; hypercalcaemia.

Storage

Oral
Store below 30°C.

Lab interference

Oral
Store below 30°C.

Clopamide brands in India:

Brindaldix

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