Tazarotene information from DrugsUpdate
P - Contraindicated in pregnancy
L - Contraindicated in lactation
Tazarotene (marketed as Tazorac, Avage and Zorac) is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). It is commonly sold in two concentrations: 0.05% and 0.1%.
Common side effects include worsening of acne, dry skin, itchiness, redness and in some cases extreme drying and cracking of skin. For most patients these side effects are uncomfortable but mild and decrease markedly after the first 2–4 weeks of use.
For best results dermatologists recommend applying the cream or gel once daily before bedtime after washing the face with a mild cleanser. Dermatologists recommend using a moisturizer with tazarotene so skin will not be as dry and flaky.
Pharmacodynamics
Pharmacokinetics
Tazarotene is a synthetic acetylenic retinoid, that is applied topically. It is de-esterified in the skin to its active form, tazarotenic acid, which affects cell proliferation and differentiation by modulating gene expression in acne and psoriasis.
Distribution
Tazarotenic acid: >99% bound to plasma proteins, half-life:18 hours.
Metabolism
Undergoes esterase hydrolysis to form its active metabolite, tazarotenic acid.
Excretion
Eliminated via urine and faeces.
Tazarotene Indications / Tazarotene Uses
Information Not Available
Tazarotene Adverse Reactions / Tazarotene Side Effects
Pruritus, burning/stinging, erythema, skin peeling, irritation, worsening of psoriasis, rash, dry skin, bleeding, localised oedema, hypertriglyceridaemia, desquamation, contact dermatitis, discolouration of skin, photosensitivity.
Precautions
Overdosage
Excessive topical use cause marked redness, peeling or discomfort. Accidental oral ingestion produces similar adverse effects as those associated with excessive oral intake of Vitamin A or other retinoids. Monitor and take supportive measures as necessary.
Special Risk Patients
Avoid use on eczematous skin and avoid concurrent use of medications and cosmetics that have a strong drying effect; assess facial pigmented lesions before use.
Photosensitivity
Use with caution if patient is known to be taking a photosensitizing drug because of increased risk of photosensitivity.
Special Precautions
Avoid contact with eyes, mouth, mucous membranes. Abraded skin. Avoid exposure to sun or UV light. Do not use >10% of BSA. Do not use cream with occlusive dressing. Wash hands after application. Do not use cream/gel in amounts more than instructed. Women of child bearing potential should take birth control measures. Negative pregnancy test to be obtained within 2 weeks prior to initiation and start therapy during normal menstrual period.
Other Drug Interactions
Increased drying effect effect with concomitant use of dermatologic medications and cosmetics that have irritant or strong drying effect. Increased risk of photosensitivity with drugs known to be photosensitisers.
Other Interactions
Information Not Available
Dosage
Topical/Cutaneous
Stable plaque psoriasis
Adult: >18 years: Apply a thin layer of 0.05% or 0.1% cream or gel to cleansed dry affected area, once daily in the evening. If needed, moisturiser should be applied at least 1 hour prior to application of tazarotene.
Topical/Cutaneous
Acne
Adult: >12 years: Apply a thin layer of 0.1% cream or gel to cleansed dry affected area, once daily in the evening.
Topical/Cutaneous
Photoaging
Adult: >17 years: Apply a thin layer of 0.1% cream or gel to cover entire face (including eyelids) once daily before retiring.
Food(before/after)
Information Not Available
List of Contraindications
Tazarotene and Pregnancy
Contraindicated in pregnancy
Tazarotene and Lactation
Contraindicated in lactation
Tazarotene and Children
Safety and efficacy not established in patients younger than 18 yr of age with psoriasis or younger than 12 years of age with acne (cream). Safety and efficacy not established in children younger than 12 years of age (gel). Safety and efficacy not established in patients younger than 17 years of age with facial fine wrinkling, facial mottled hypo- and hyperpigmentation, and benign facial lentigines ( Avage ).
Tazarotene and Geriatic
Information Not Available
Tazarotene and Other Contraindications
Pregnancy, lactation. Eczema. Sunburnt conditions. Hypersensitivity.
Storage
Information Not Available
Lab interference
Information Not Available
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