logo image

Sumatriptan information from DrugsUpdate  

See Available Brands of Sumatriptan in India

P - Caution when used during pregnancy
L - Caution when used during lactation
FI - Food *

Sumatriptan (trade names Imitrex, Imigran, Imigran recovery) is a triptan drug including a sulfonamide group for the treatment of migraine headaches. It is marketed and manufactured by GlaxoSmithKline as well as various generic drug manufacturers.

Pharmacodynamics

Pharmacokinetics

Sumatriptan is a selective serotonin agonist that acts at 5-HT1 receptors. It causes vasoconstriction of cranial arteries and/or inhibition of neurogenic inflammatory processes in the CNS. A small but significant delay in gastric emptying also occurs.

Onset
Oral
30 minutes; Intranasal: 15 minutes; subcutaneous: 10-15 minutes.

Absorption
Rapidly but incompletely absorbed from the GIT (oral); peak plasma concentrations reached in 2 hours (oral), 25 minutes (subcutaneous), 1.5 hours (intranasal). Bioavailabilty for oral is 14%, subcutaneous 96% and intranasal is 16% of that achieved in subcutaneous.

Distribution

Enters breast milk. Protein-binding: 14-21%

Metabolism
Extensive first-pass metabolism by MAO type A

Excretion
Mainly via urine (as inactive indole acetic acid derivative and its glucuronide), via faeces (as unchanged drug and metabolites). Elimination half-life: 2 hours.

Sumatriptan Indications / Sumatriptan Uses

Information Not Available

Sumatriptan Adverse Reactions / Sumatriptan Side Effects

Transient hypertension, hypotension, dizziness, flushing, fatigue, drowsiness, weakness, seizures, nausea and vomiting, heat, tightness in any part of body, paraesthesia, seizures, inj site reactions, irritation of nasal mucosa and epistaxis. Rebound headache with frequent use.

Potentially Fatal: Cardiac arrhythmias, MI.

Precautions

Information Not Available

Special Precautions

Conditions predisposing to seizures, presence of coronary risk factors, cardiac arrhythmias, renal or hepatic impairment, elderly, pregnancy, lactation.

Other Drug Interactions

Concurrent use increased risk of vasospastic reaction with ergotamine and related compounds.

Potentially Fatal: Increased risk of serotonin syndrome with concurrent use of SSRI, MAOIs or within 14 days of stopping MAOIs. Admin of ergotamine or related compounds within the previous 24 hours.

Other Interactions

Food Interaction
Increased serotonergic effectsand adverse events with concurrent use of St John's Wort.

Dosage

Oral
Migraine
Adult: >18 years: 50-100 mg repeated at 2-hours intervals if migraine recurs. Max: 300 mg/24 hours.
Hepatic impairment: Max: 50 mg/day.

Subcutaneous
Migraine
Adult: >18 years: 6 mg as a single dose injection, repeated at least 1 hour after the 1st dose if symptoms persist. Max: 12 mg/24 hours.
Hepatic impairment: Dose reduction needed.

Subcutaneous
Cluster headache
Adult: >18 years: 6 mg as a single dose injection, repeated at least 1 hour after the 1st dose if symptoms persist. Max: 12 mg/24 hours.
Hepatic impairment: Dose reduction needed.

Nasal
Migraine
Adult: 12-17 years: 10 mg into 1 nostril, repeated at least 2 hours after the 1st dose if symptoms recur. Max: 20 mg/24 hours. >18 years: 20 mg into 1 nostril, repeated at least 2 hours after the 1st dose if symptoms recur. Max: 40 mg/24 hours.
Hepatic impairment: Dose reduction needed.

Food(before/after)

May be taken with or without food

List of Contraindications

Sumatriptan and Pregnancy

Caution when used during pregnancy

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Sumatriptan and Lactation

Caution when used during lactation

Sumatriptan and Children

Safety and efficacy not established

Sumatriptan and Geriatic

Use is not recommended because elderly patients are more likely to have decreased hepatic function, they are at higher risk of coronary artery disease, and blood pressure increases may be more pronounced.

Sumatriptan and Other Contraindications

Not to be used prophylactically and in patients with basilar or hemiplegic or ophthalmoplegic migraine. History of MI or stroke, severe hepatic impairment, ischaemic heart disease, uncontrolled hypertension, peripheral vascular disease, hypersensitivity to sulfonamides.

Storage

Nasal
Store below 30°C. Do not freeze.

Oral

Store below 30°C.

Subcutaneous

Store below 30°C.

Lab interference

Nasal
Store below 30°C. Do not freeze.

Oral

Store below 30°C.

Subcutaneous

Store below 30°C.

Sumatriptan brands in India:

Headset Migratan Suminat Sumisun Sumitrex

© 2011-2021 DrugsUpdate.com from UPilot INC. Disclaimer | Site Map

Feedback
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to millions of Visitors instantly.
  • Companies that own platforms will own the market
  • Trusted and recognized by all Doctors
  • Access to millions of Visitors instantly.