Sulfacetamide information from DrugsUpdate
P - Caution when used during pregnancy
L - Caution when used during lactation
LI - Lab *
Sulfacetamide is a sulfonamide antibiotic.
Pharmacodynamics
Pharmacokinetics
Sulfacetamide has bacteriostatic effect on a wide range of gram-positive and gram-negative organisms. It interferes with nucleic acid synthesis thus blocking conversion of PABA to the coenzyme dihydrofolic acid.
Absorption
Penetrates into ocular tissues and fluids (ophthalmic).
Excretion
Urine (as unchanged drug); 7-13 hours (elimination half-life).
Sulfacetamide Indications / Sulfacetamide Uses
Information Not Available
Sulfacetamide Adverse Reactions / Sulfacetamide Side Effects
Hypersensitivity skin reaction. Ophthalmic: Burning, stinging, conjunctivitis, corneal ulcers, irritation, conjunctival hyperaemia. Systemic absorption from inflamed conjunctiva.
Potentially Fatal: Stevens-Johnson syndrome.
Precautions
Prolonged use of topical anti-bacterial agents may give rise to overgrowth of nonsusceptible organisms including fungi. Bacterial resistance to sulfonamides may also develop.
Special Precautions
Elderly. History of allergy or asthma; G6PD deficiency; renal and hepatic impairment. Prolonged therapy requires CBC and urinalysis with microscopic examination. Maintain adequate fluid intake. Pregnancy, lactation.
Other Drug Interactions
Action antagonised by PABA and procaine group of local anaesthetics. PABA present in purulent eye exudates can competitively inhibit the action of sulphacetamide.
Other Interactions
Information Not Available
Dosage
Ophthalmic
Ocular infections
Adult: As sodium: Apply 10-30% eye drops or 10% ointment into the affected eye/s. May be used up to tid.
Food(before/after)
Information Not Available
List of Contraindications
Sulfacetamide and Pregnancy
Caution when used during pregnancy
Sulfacetamide and Lactation
Caution when used during lactation
Sulfacetamide and Children
Information Not Available
Sulfacetamide and Geriatic
Information Not Available
Sulfacetamide and Other Contraindications
Hypersensitivity; infants <2 months
Storage
Ophthalmic
Store below 25°C.
Lab interference
Ophthalmic
Store below 25°C.
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